Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-11-08
2010-11-16
Kifle, Bruck (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S232800, C514S252110, C514S253110, C514S254110, C514S338000, C514S397000, C514S422000, C514S431000, C540S549000, C540S550000, C544S145000, C544S357000, C544S364000, C544S378000, C546S279700, C548S311700, C548S526000, C549S010000
Reexamination Certificate
active
07834001
ABSTRACT:
Guanidine derivatives having a condensed tricyclic ring of formula 1:are disclosed, wherein U is C(O), CRaRb, O, NRaor S(O)m; V is CRaRbor NRa; W is S(O)m; wherein Rais H, alkyl, cycloalkyl, alkenyl or aralkyl; Rbis H, alkyl, OH, ORaor OCORa, and m is the integer 0, 1 or 2; R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein with the proviso that at least one of R1, R2, R3, R4, R5, R6, R7 or R8 is guanidino or guanidino carbonyl. These derivatives are sodium-proton exchange inhibitors and are useful as medicaments for the treatment of, for example, organ disorders associated with ischemia and reperfusion, cardiac arrhythmia, cardiac hypertrophy, hypertension, cell proliferative disorders and diabetes.
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Bal-Tembe Swati
Ghosh Usha
Jain Arun Kumar
Lal Bansi
More Tulsidas
Kifle Bruck
Merchant & Gould P.C.
Piramal Life Sciences Limited
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