Tricyclic glycinamide derivatives as anti-convulsants

Details Tricyclic glycinamide derivatives as anti-convulsants Tricyclic glycinamide derivatives as anti-convulsants

1991-06-25

1992-08-25

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

5142275, 5142375, 514255, 514325, 514423, 514616, 514617, 514618, 514620, 544 584, 544154, 544155, 544380, 546195, 548528, 564153, 564154, 564156, 564162, 564163, 564166, 564167, 564168, A61K 31165, C07C23714

Patent

active

051419602

ABSTRACT:
A class of tricyclic glycinamide derivatives is described having use in treatment of CNS dysfunctions such as epilepsy and convulsive disorders. Compounds of most interest are those of the formula ##STR1## wherein each of X and Y is hydrido; wherein Z is selected from methylene, ethylene, ethenylene, thiomethylene and thioethylene; and wherein each of R.sup.1, R.sup.2 and R.sup.3 is hydrido; or a pharmaceutically-acceptable salt thereof.

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V. A. Shibnev et al, Bioorg. Khim., 10(7), 921-926 (1984).

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