Tricyclic fused adenine derivatives

Details Tricyclic fused adenine derivatives Tricyclic fused adenine derivatives

1991-06-04

1992-02-04

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544267, C07D47300, C07D48712, A61K 31645

Patent

active

050861760

ABSTRACT:
Adenosine analogues which act selectively at adenosine receptors and which act in general as adenosine antagonists are disclosed. From in vitro studies it is known that specific physiological effects can be distinguished as a result of this selectivity and that adenosine receptor activity in vitro correlates with adenosine receptor activity in vivo. Pharmaceutical preparations of the subject compounds can be prepared on the basis of the selective binding activity of the compounds disclosed herein which can be expected to enhance certain physiological effects while minimizing others, such as decreasing blood pressure without decreasing heart rate.

REFERENCES:
patent: 3830795 (1974-08-01), Prasad et al.
patent: 3830796 (1974-08-01), Prasad et al.
patent: 3931401 (1976-01-01), Prasad et al.
patent: 4007268 (1977-02-01), Voorhees

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