Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...
Patent
1995-10-11
1997-01-14
Datlow, Philip I.
Organic compounds -- part of the class 532-570 series
Organic compounds
Unsubstituted hydrocarbyl chain between the ring and the -c-...
540469, A61K 31395, C07D51508, C07D51518
Patent
active
055941354
ABSTRACT:
The present invention relates to a compound of the formula ##STR1## wherein X.sup.1, R.sup.1, R.sup.2, OP, R.sup.3, R.sup.4, R.sup.5, R.sup.6, and R.sup.0 are as described herein, and their pharmaceutically acceptable salts thereof carrying an acidic and/or basic substituent.
The compound of formula I as well as their pharmaceutically acceptable salts inhibit DNA gyrase activity in bacteria and possess antibiotic, especially antibacterial activity against microorganisms and can be used in the control or prevention of infectious diseases.
REFERENCES:
patent: 5294609 (1994-03-01), Arisawa et al.
Goetschi, E., et al., Pharmac. Ther., 60:367-380 (1993).
Goetschi, E., et al., Chemical Abstract 121:124616 (1993).
Kamiyama, Tsutomu, et al., The Journal of Antibiotics, 47(1):37-45 (1993).
Kamiyama, Tsutomu, et al., Chemical Abstract 120:212154z (1994).
The Merck Manual, 15th ed. (1987), Berkow, M.D., editor, p. 46.
G otschi Erwin
Geiwiz J urgen
Hebeisen Paul
L ubbers Thomas
Link Helmut
Datlow Philip I.
Hoffmann-La Roche Inc.
Johnston George W.
Kass Alan P.
Tramaloni Dennis P.
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