Tricyclic derivatives, compositions and methods of use

Details Tricyclic derivatives, compositions and methods of use Tricyclic derivatives, compositions and methods of use

1993-12-06

1996-11-12

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

564427, C07D31310, C07C21131, A61K 31335, A61K 31135

Patent

active

055741738

ABSTRACT:
Disclosed are compounds of Formula I: ##STR1## or a pharmaceutically acceptable salt or solvate thereof, wherein: R.sup.4 is alkenyl, alkoxy, or --OH.
Also disclosed are pharmaceutical compositions containing compounds of Formula I, methods for inhibiting tumor necrosis factor-.alpha., and methods for treating septic shock, inflammation, or allergic disease.

REFERENCES:
patent: 3372196 (1968-03-01), Engelhardt
patent: 3438981 (1969-04-01), Stach
patent: 3535315 (1970-10-01), Winter et al.
patent: 3595865 (1971-07-01), Sorenson et al.
patent: 3639423 (1972-02-01), Winter et al.
patent: 3674841 (1972-07-01), Boissier et al.
patent: 3922305 (1975-11-01), Engelhardt
patent: 3927128 (1975-12-01), Kyburz et al.
patent: 3944566 (1976-03-01), Winter et al.
patent: 3965181 (1976-06-01), Marx
patent: 3978121 (1976-08-01), Engelhardt
patent: 3981917 (1976-09-01), Englehardt
patent: 3991103 (1976-11-01), Barton et al.
patent: 4070373 (1978-01-01), Winter et al.
patent: 4496557 (1985-01-01), Malen et al.
patent: 4585788 (1986-04-01), Helsey et al.
patent: 4626542 (1986-12-01), King et al.
patent: 4645758 (1987-02-01), Willman et al.
patent: 4826853 (1989-05-01), Piwinski et al.
patent: 4996321 (1991-02-01), Baldwin et al.
patent: 5089496 (1992-02-01), Piwinski et al.
patent: 5104876 (1992-04-01), Piwinski et al.
patent: 5140027 (1972-08-01), Ong et al.
patent: 5151423 (1992-09-01), Piwinski et al.
Chem. Abstracts Reg. No. 55286-80-1 (1992).
Chem. Abstracts Reg. No. 23509-37-7 (1992).
Chem. Abstracts Reg. No. 23485-60-1 (1992).
Chem. Abstracts Reg. No. 138729-88-1 (1993).
Chem. Abstracts Reg. No. 138707-21-8 (1993).
Chem. Abstracts Reg. No. 37028-07-2 (1993).

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