Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-09-11
1999-09-28
Huang, Evelyn Mei
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546 93, A61K 3144, C07D40114
Patent
active
059589400
ABSTRACT:
Novel tricyclic compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel tricyclic compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammals such as a human.
REFERENCES:
patent: 5696121 (1997-12-01), Bishop
patent: 5703090 (1997-12-01), Afonso
Khosravi-Far R et al. Cell Growth & Differentiation. 3, pp. 461-469, Jul. 1992.
Cooper Alan B.
Doll Ronald J.
Mallams Alan K.
Njoroge F. George
Rane Dinanath F.
Huang Evelyn Mei
Majka Joseph T.
Schering Corporation
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