Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Reexamination Certificate
2011-07-19
2011-07-19
Wilson, James O (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
Reexamination Certificate
active
07982035
ABSTRACT:
The present invention provides tricyclic compounds, pharmaceutically acceptable salts, prodrugs, solvates, or hydrates thereof, having antimitotic activity, anti-multidrug resistance activity, for example P-glycoprotein inhibition, and antitumor activity, and which inhibit paclitaxel sensitive and resistant tumor cells. Also provided are methods of utilizing these compounds for treating tumor cells and inhibiting mitosis of cancerous cells.
REFERENCES:
patent: 4769378 (1988-09-01), Hirsch et al.
patent: 5679683 (1997-10-01), Bridges et al.
patent: 6596726 (2003-07-01), Bridges et al.
patent: WO 2006/136402 (2006-12-01), None
Showalter, et al., Tyrosine Kinase Inhibitors. 16. 6,5,6-Tricyclic Benzothieno[3,2-d]pyrimidines and Pyrimido[5,4-b]- and -[4,5-b]indoles as Potent Inhibitors of the Epidermal Growth Factor Receptor Tyrosine Kinase, Journal of Medicinal Chemistry 42(26), 5464-5474 (1999).
Konno, et al., Synthesis of thieno[2,3-d]pyrimidine derivatives and their antifungal activities, Yakugaku Zasshi 109(7), 464-73 (1989).
Yamaguchi, et al., 3,4-Dihydrothienopyrimidines. II. Synthesis and Sodium borohydride reduction of 2-substituted 4-chloro- and 4-unsubstituted-thieno[2,3-d]pyrimidines, Chemical & Pharmaceutical Bulletin 30(1), 326-32 (1982).
Wolff, Manfred E., Burger's Medicinal Chemistry and Drug Discovery, Fifth Ed., vol. 1: Principles and Practice, John Wiley & Sons, 1995, 975.
Banker, Gilbert S. et al., Modem Pharmaceutics, Marcel Dekker, New York, 1996.
International Search Report (PCT/ISA/210) and Written Opinion of the International Searching Authority (PCT/ISA/237) for PCT/US2009/049913 dated Aug. 24, 2009.
Buchanan & Ingersoll & Rooney PC
Cochenour Craig G.
Duquesne University of the Holy Spirit
Leeser Erich A
Wilson James O
LandOfFree
Tricyclic compounds having antimitotic and/or antitumor... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Tricyclic compounds having antimitotic and/or antitumor..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tricyclic compounds having antimitotic and/or antitumor... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2706584