Tricyclic compounds, compositions, and methods useful in the...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S220000, C540S557000, C540S580000

Reexamination Certificate

active

07960374

ABSTRACT:
The present invention relates to compounds of the formula (I)wherein A, X and R1to R9are as described herein; to pharmaceutical compositions comprising the said compounds; to processes for their preparation; and to the use of the compounds as medicaments against 5-HT6receptor-related disorders.

REFERENCES:
patent: 7056942 (2006-06-01), Hildesheim et al.
patent: WO-01/32646 (2001-05-01), None
patent: WO-01/32660 (2001-05-01), None
patent: WO-2005/037834 (2005-04-01), None
patent: WO-2005/047252 (2005-05-01), None
Jantzen and Robinson, Modern Pharmaceutics, p. 596.
Guo et al. Journal of Nuclear Medicine, 2009, 50(10), pp. 1715-1723.
Zhou et al., “4-(2-Aminoethoxy)-N-(phenylsulfonyl)indoles as novel 5-HT6receptor ligands”, Bioorganic & Medicinal Chem. Letters, vol. 15, No. 5, 2005, pp. 1393-1396.
Cole et al., “N1-arylsulfonyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives are potent and selective 5-HT6receptor antagonists”, Bioorganic & Medicinal Chem. Letters, vol. 15, 2005, pp. 379-383.

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