Tricyclic compounds as modulators of TNF-α synthesis

Details Tricyclic compounds as modulators of TNF-α synthesis Tricyclic compounds as modulators of TNF-α synthesis

2011-06-21

2011-06-21

Kosar, Andrew D (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S250000

Reexamination Certificate

active

07964608

ABSTRACT:
The present invention relates to chemical compounds of Formula (I) are as herein defined, pharmaceutical compositions, and methods of use in the treatment of conditions or disorders mediated by TNF-alpha or by PDE4, including but not limited to rheumatoid arthritis.

REFERENCES:
patent: 4927820 (1990-05-01), Shutske et al.
patent: 5834485 (1998-11-01), Dyke et al.
patent: 2005/0065116 (2005-03-01), Carson et al.
patent: 193012 (2004-12-01), None
patent: 2007/004958 (2007-01-01), None
Zahran, et al., Synthesis of some pyrimidines and their benzo-derivatives via 6 p-electron cyclization reactions, Afinidad, 52(460), 415-18 (1995).
Katritzky, et al., Polycyclic Heteroaromatics from Reactions of Acylbenzotriazoles with Aryl Isocyanates, Journal of Organic Chemistry 65(23), 8069-8073 (2000).
Reimund, et al., Anti-TNF-α Properties of New 9-Benzyladenine Derivatives with Selective Phosphodiesterase-4-Inhibiting Properties, Biochemical and Biophysical Research Communications, 288, 427-434 (2001).
Geis, U. et al., “Tricyclic Theophylline Derivatives with High Water Solubility: Structure-Activity Relationships at Adenosine Receptors, Phosphodiesterases, and Benzodiazepine Binding Sites” Pharmazie, vol. 50(5), pp. 333-336 (1995).
Nargund, V. G. et al., “Synthesis and Antimicrobial and Anti-inflammatory Activities of Substituted 2-Mercapto-3-(N-aryl)pyrimido[5,4-c]cinnolin-4-(3H)-ones” J. Pharm. Sci., vol. 81(4), pp. 365-366 (1992).
Stanczak et al., “Synthesis and biological activity of some 4-amino-3-cinnoline carboxylic acid derivatives” Pharmazie, vol. 53(3), pp. 156-161 (1998).
Haider & Holzer, “Product Class 9: Cinnolines” in Science of Synthesis, vol. 16, pp. 251-313 (2004).
Stanczak et al., “Comparison of pharmacophore cinnoline and quinoline systems on the basis of computer calculation and pharmacological screening of their condensed systems” Pharmazie, vol. 56(6), pp. 501-505 (2001).
Menon et al., “Synthesis and Antimicrobial Properties of Pyrimido[5,4-c]cinolin-2,4(1H,3H)-diones” J. Indian Chem. Soc., vol. 72(10), pp. 731-733 (1995).
Lewgowd et al., “Determination of Lipophilicity, pKa Measurement and Action on the Central Nervous System of Some Pyrimido[5,4-c]quinolines” Acta Poloniae Pharm., vol. 62(4), pp. 271-281 (2005).
Lewgowd et al., “Synthesis and cytotoxicity of new potential intercalators based on tricyclic systems of some pyrimido[5,4-c]cinnoline and pyrimido[5,4-c]quinoline derivatives. Part l” Acta Poloniae Pharm., vol. 62(2), pp. 105-110 (2005).
Stanczak et al., “Determination of the Lipophilicity of Pyrimido[5,4-c]quinoline Derivatives by Reversed-Phase Thin-Layer Chromatography. Part 1. Lipophilicity of Pyrimido[5,4-c]quinolin-4(3H)-ones and 1,2,3,4-Tetrahydropyrimido[5,4- c]quinolin-2,4-diones” J. Planar Chromatography—Modern TLC, vol. 15(3), pp. 169-176 (2002).
Shindo et al., “Synthesis of Heterocyclic Compounds Isosterically Related to Pyrazolo[4,3-c]quinolines as Benzodiazepine Receptor Ligands” Heterocycles, vol. 29(5), pp. 899-912 (1989).
Haede et al., “Herstellung Kondensierter 2-Alkylthio-4-hydroxypyrimidine” J. Heterocyclic Chem., vol. 18(7), pp. 1417-1419 (1981).
International Search Report for PCT/US09/031819, dated Mar. 25, 2009.
International Preliminary Report on Patentability for PCT/US09/031819, dated Jul. 27, 2010.
Chemical Abstracts Registry Entry 375362-97-3, entered Dec. 14, 2001.

Affiliated with

Also associated with

Rating

Tricyclic compounds as modulators of TNF-α synthesis does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Tricyclic compounds as modulators of TNF-α synthesis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tricyclic compounds as modulators of TNF-α synthesis will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2694876