Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-06-21
2005-06-21
McKenzie, Thomas C. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S220000, C540S558000, C540S590000, C540S591000, C540S592000
Reexamination Certificate
active
06908915
ABSTRACT:
A compound having a general formula (II) wherein R1is saturated or unsaturated alkyl, amino-alcohol, diamino, cycloalkyl, and C(═O)(CH2)nNR′R″, (CH2)nCHOHCH2NR′R″, wherein n is an integer, RQ, RT, R′, and R″ are each independently a hydrogen, halogen, hydroxyl, saturated, unsaturated, aliphatic, or branched alkyl, substituted or unsubstituted (CH2)m-(hetero)aryl, and sulfonylamide; q and r are each an integer independently selected from 1-4; and pharmaceutically acceptable salts thereof, and the new therapeutic uses thereof and similar compounds as defibrillating, and/or anti-fibrillatory, and/or anti-arrhythmic and/or anti-ischemic drugs.
REFERENCES:
patent: 2976281 (1961-03-01), Schindler et al.
patent: 3335133 (1967-08-01), Kaiser et al.
patent: 3842091 (1974-10-01), Kawashima et al.
patent: 4495281 (1985-01-01), Buckler et al.
patent: 4668640 (1987-05-01), Wang et al.
patent: 5002943 (1991-03-01), Mihm et al.
patent: 5066426 (1991-11-01), Wang et al.
patent: 5264432 (1993-11-01), Rüger et al.
patent: 0515796 (1992-12-01), None
Lin, John W. P. Journal of Polymer Science, Polymer Chemistry Edition, 17(12), 3797-810 (English) 1979.
Gozlan, Igal; Halpern, Marc; Rabinovitz, Mordecai; Avnir, David; Ladkani, David, IJournal of Heterocyclic Chemistry, 19(6), 1569-71 (English) 1982.
Olshausen et al, “Sudden Cardiac Death While Wearing Holter Monitor”,Am J Cardiol,67(5):381-386, 1991 (Abstract).
Williams, V., “Classifying Antiarrhythemic Actions: By Facts or Speculation”,J Clin Pharmacol,32(11):964-977, 1992 (Abstract).
(No author listed) “Preliminary Report: Effect of Encainde and Flecainide on Mortality in a Ransomized Trial of arrhythmia Suppression after Myocardial Infarction. Cardia Arrhythmia Suppression Trail (CAST) Investigators”,N. Engl J Med,321(6):406-412, 1989 (Abstract).
Manoach et al, “Spontaneous Termination of Electrically Induced Ventricular Fibrillation”, Progress in Electrocardiology, Glasgow, Ed. P. MacFarlane. Pitman Medical, pp 361-365, 1979.
Manoach et al, “Spantaneous Termination and Initiation of Ventricular Fibrillation as a Function of Heart Size, Age, Autonomic Autoregulation, and drugs: A Comparative Study on Different Species of Different Age”,Heart Vessels,Suppl.2:56-68, 1987.
Manoach et al, “Reduction of Infarct Size Following Acute Coronary Occlusion by Augmenting Collateral Blood Supply Induced by Infusion of Tricyclic Antidepressants”,Heart Vessels, 3:80-83, 1987.
Manoach et al, “The Cardio-Protective Features of Tricyclic Antidepressants”,Gen. Pharmac.,20(3):269-275, 1989.
Manoach et al, “Propertis Required for Self-Ventricular Defibrillation: Influence of Age and Drugs”,Cardiology in the Elderly,1:337-344, 1993.
Manoach et al, “The Role of Catecholamines on Intercellular Coupling, Myocardial Cell Synchronization and Self Ventricular Defibrillation”,Molecular and Cellular Biochemistry,147:181-185, 1995.
Erez et al, “Dibenzazepines and Phenothiazines—A Winding Path to Defibrillatory Antiarrhythmic Agents”,Exp. Clin. Cardiol.,2(1):59-63, 1997.
Kaverina et al, “New Cardiovascular Drugs among Phenothiazine Derivitives and Related Tricyclic Systems”,Sov. Med. Rev. A. Cardiology,3:81-100, 1991.
Erez Mordechai
Keinan Ehud
Levy Ofra
G. E. Ehrlich (1995) Ltd.
McKenzie Thomas C.
Technion Research & Development Foundation Ltd.
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