Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-02-22
2005-02-22
Raymond, Richard L. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S248000, C514S245000, C514S250000, C514S252160, C514S252130, C514S211010, C544S336000, C544S387000, C544S358000, C544S380000, C544S384000, C540S543000, C540S547000, C540S553000, C540S557000, C540S569000, C540S570000
Reexamination Certificate
active
06858599
ABSTRACT:
This invention relates to tricyclic compounds having spiro union represented by the following formula (I) or its salt which is useful as a drug, and in particular, as an inhibitor for activated blood coagulation factor X, which can be administered orally and which exhibits strong anticoagulation action.The invention also relates to a pharmacophore which was derived from the compound and is useful in molecular designing of the FXa inhibitor.
REFERENCES:
patent: 5292747 (1994-03-01), Davis et al.
patent: 5691356 (1997-11-01), Das et al.
patent: 0 300 541 (1989-01-01), None
patent: 9616940 (1996-06-01), None
Copy of claims of U. S. Sr #v10451728, fied Jun. 25, 2003.*
Brandstetter et al., J. Biological Chemistry, vol. 271, No. 47 (1996) pp. 29988-29992.
Kamata et al., Proc. Natl. Acad. Sci USA, vol. 95 (1998) pp. 6630-6635.
Mochalkin et al., Acta Cryst, D55 (1999) pp. 785-793.
Maduskuie et al., Book of Abstracts, 214thACS National Meeting, Las Vegas (1997) MEDI-048.
Wiley ate al., Book of Abstracts, 218thACS National Meeting, New Orleans (1999) MEDI-026.
Ostrem et al., Biochemistry, vol. 37 (1998) pp. 1053-1059.
Hauptmann et al., Thrombosis Research 93 (1999) pp. 203-241.
Harada Kousuke
Mukaihira Takafumi
Nishida Hidemitsu
Saitoh Fumihiko
Shiromizu Ikuya
Birch & Stewart Kolasch & Birch, LLP
Mochida Pharmaceutical Co. Ltd.
Patel Sudhaker B.
Raymond Richard L.
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