Tricyclic compound and use thereof

Details Tricyclic compound and use thereof Tricyclic compound and use thereof

2011-06-21

2011-06-21

Desai, Rita J (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S079000, C514S278000, C514S290000

Reexamination Certificate

active

07964726

ABSTRACT:
The present invention relates to the compound represented by formula (I):(wherein, all the symbols has the same meanings as that of the specification), a salt thereof, a solvate thereof or a prodrug thereof.Since the compound of the present invention has an anti stress action, it is useful for preventive and/or therapeutic agent for a disease caused by stress, especially a digestive system disease caused by stress and is superior to oral absorption.

REFERENCES:
patent: 3959470 (1976-05-01), Mashkovskym et al.
patent: 4336260 (1982-06-01), Payne et al.
patent: 5095020 (1992-03-01), Hulkenberg et al.
patent: 5403851 (1995-04-01), D'Orlando et al.
patent: 6043252 (2000-03-01), Bombrun
patent: 6048868 (2000-04-01), Fourtillan et al.
patent: 6350757 (2002-02-01), Goldstein et al.
patent: 7368444 (2008-05-01), Seko et al.
patent: 7403851 (2008-07-01), Kaufman et al.
patent: 2002/0010189 (2002-01-01), Sui
patent: 2004/0072833 (2004-04-01), Nakai et al.
patent: 2004/0116458 (2004-06-01), Sawyer et al.
patent: 2004/0122035 (2004-06-01), Orme et al.
patent: 2004/0132735 (2004-07-01), Troxler et al.
patent: 2004/0147542 (2004-07-01), Sawyer et al.
patent: 2004/0152736 (2004-08-01), Chackalamannil et al.
patent: 2006/0154944 (2006-07-01), Ohmoto et al.
patent: 0740668 (1998-07-01), None
patent: 1 438 973 (2004-07-01), None
patent: 1 475 368 (2004-11-01), None
patent: 1431702 (1976-04-01), None
patent: 1444980 (1976-08-01), None
patent: 3-287586 (1991-12-01), None
patent: 09-508113 (1997-08-01), None
patent: 9-511246 (1997-11-01), None
patent: 2001-072679 (2001-03-01), None
patent: 2002-517500 (2002-06-01), None
patent: 2002-524564 (2002-08-01), None
patent: 2004-501919 (2004-01-01), None
patent: 2004-518729 (2004-06-01), None
patent: 2004-518730 (2004-06-01), None
patent: 2004-518730 (2004-06-01), None
patent: 2004-532852 (2004-10-01), None
patent: 95/26723 (1995-10-01), None
patent: 97-43287 (1997-11-01), None
patent: 99-64420 (1999-12-01), None
patent: 00-015639 (2000-03-01), None
patent: 01-87038 (2001-11-01), None
patent: 02-00657 (2002-01-01), None
patent: 02-053565 (2002-07-01), None
patent: 02-064590 (2002-08-01), None
patent: 02-064591 (2002-08-01), None
patent: 02-064591 (2002-08-01), None
patent: 02-081471 (2002-10-01), None
patent: 02-088123 (2002-11-01), None
patent: 03-068753 (2003-08-01), None
patent: 03/099821 (2003-12-01), None
patent: 2004-113300 (2004-12-01), None
patent: 2005/070930 (2005-08-01), None
patent: 2005/089764 (2005-09-01), None
Dorwald F. A. Side Reactions in Organic Synthesis, 2005, Wiley: VCH, Weinheim p. IX of Preface.
Limbach, M et al, Addition of Indole to methyl 2-chloro-2-cyclopropylideneacetate en route to Spirocyclopropanated Analogues or Demethoxyfumitremorgine C and Tadalafil,, Eur . J. Org. Chem., 2005, vol. 3, pp. 610 to 617.
Yakhontov, L. N. et al., Azaindole derivatives,. XXXVIII. Normal and abnormal course of reactions during 12-aza-B-carboline synthesis, Khimiya Geterotsiklicheskikh Soedinenii, 1970, vol. 11, pp. 1550-1553.
Cain, M. et al., b-Carbolines: Synthesis and Neurochemical and Pharmacological actions on brain benzodiazepine receptors, J. Med. chem., 1982, vol. 25, 1081-1091.
Extended European Search Report issued in Appl. No. 05820106.2-2101/1829874, dated Dec. 3, 2009.
Chemical Abstracts Service; C. Balsamini, et al.; “N-benzhydryltryptamines and 1, 1-diphenyltetrandro-.beta.-carbolines: synthesis, x-ray crystal structure and benzodiazepine receptor affinity” XP002556789; retrieved from STN—Database accession No. 1989:526474; ISSN: 0014-827X; 1989; 2 pages in total.
International Search Report (PCT/ISA/210) for PCT/JP2004/009071, dated Oct. 5, 2004.
Manfred E. Wolff; “Burger's Medicinal Chemistry and Drug Discovery”; John Wiley & Sons, Inc., 19 vol. 1; 1995, pp. 975-977.
F. Zaragoza Dorwald; Side Reactions in Organic Synthesis, 2005; Wiley: VCH, Weinheim; p. IX of Preface.
Gilbert S. Banker; “Modern Pharmaceutics, 3rdEdition, Revised and Expanded.”, Marcel Dekker, New York, 1996, pp. 451 and 596.
European Offce Action for Application No. 04746540.6-2101 / 1637521, dated Jul. 29, 2009.
Michikazu Abe,et al.; “Reduction of Wrap Restraint Stress-Induced Defecation by MKC-242, a Novel Benzodioxan Derivative, via 5-HT1A-Receptor Agonist Action in Rats.”; Jpn. J. Pharmacol.; 1998; vol. 77; 211-217.
B. Bonaz, et al.; “Water-avoidance stress-inducedc-fosexpression in the rat brain and stimulation of fecal output: role of corticotropin-releasing factor”; 1994, Elsevier Science B.V., Brain Research, 641, pp. 21-28.
Haishan Wang, et al.; “Synthesis and Evaluation of Tryprostatin B and Demethoxyfumitremorgin C Analogues”; J. Med. Chem.; 2000 American Chemical Society, vol. 43, pp. 1577-1585.
Brian E.Love, et al.; “Preparation of I-Aryl- β-carbolines”; J. Org. Chem., 1994, vol. 59 No. 11; pp. 3219-3222.
Office Action (Non-final) issued on May 19, 2009 for U.S. Appl. No. 10/561,973.

Affiliated with

Also associated with

Rating

Tricyclic compound and use thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Tricyclic compound and use thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tricyclic compound and use thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2641332