Tricyclic carbamate compounds useful for inhibition of G-protein

Details Tricyclic carbamate compounds useful for inhibition of G-protein Tricyclic carbamate compounds useful for inhibition of G-protein

1995-05-31

1998-03-17

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544361, 546 94, A61K 31495, C07D40104, C07D40114

Patent

active

057287031

ABSTRACT:
A method of inhibiting Ras function and therefore inhibiting cellular growth is disclosed. The method comprises the administration of a compound of Formula. 1.0 ##STR1## Also disclosed are novel compounds of the formulas: ##STR2## Also disclosed are processes for making 3-substituted compounds of the Formulas 1.1, 1.2 and 1.3.
Further disclosed are novel compounds which are intermediates in the processes for making the 3-substituted compounds of Formulas 1.1, 1.2, and 1.3.

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