Tricyclic cage compounds, their synthesis and use as antiviral a

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Allergen or component thereof

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549 43, 549 46, 549 26, 549 27, 549 12, 424285, 424283, 549263, 549281, 549349, 549386, 549459, A61K 3138, A61K 3134, A61K 3135, C07D30792

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043472540

ABSTRACT:
A compound of the formula: ##STR1## wherein A.sub.1 is a single bond or a C.sub.1 -C.sub.5 alkylene group bonding at the 2-, 2'- or 3-position, A.sub.2 is a C.sub.1 -C.sub.3 alkylene group, A.sub.3 is a C.sub.1 -C.sub.4 alkylene group, X is --O-- or --SO.sub.n -- and B is a carboxy group, a C.sub.2 -C.sub.5 alkoxycarbonyl group, a cyano group, an amino group of the formula: ##STR2## or a carbamoyl group of the formula: ##STR3## which is useful as an antiviral agent with no side effect.

REFERENCES:
patent: 3346596 (1967-10-01), Hoch et al.
patent: 3401179 (1968-09-01), Wiese et al.
Tetrahedron Letters, No. 19, pp. 1165-1170, 1964, Moriarty, et al.
Crundwell, et al., Tetrahedron, vol. 34, pp. 1043-1045, 1978.
J. Org. Chem., vol. 41, No. 7, 1976, pp. 1229-1233.
Tetrahedron Letters, No. 46, pp. 4003-4006, 1970.
J. of Org. Chem., vol. 38, No. 10, 1973, pp. 1803-1806.
J.A.C.S., vol. 89, Jul. 19, 1967, pp. 3927-3929.

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