Tricyclic cage compounds, their synthesis and use as antiviral a

Details Tricyclic cage compounds, their synthesis and use as antiviral a Tricyclic cage compounds, their synthesis and use as antiviral a

1980-07-22

1982-08-31

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Allergen or component thereof

549 43, 549 46, 549 26, 549 27, 549 12, 424285, 424283, 549263, 549281, 549349, 549386, 549459, A61K 3138, A61K 3134, A61K 3135, C07D30792

Patent

active

043472540

ABSTRACT:
A compound of the formula: ##STR1## wherein A.sub.1 is a single bond or a C.sub.1 -C.sub.5 alkylene group bonding at the 2-, 2'- or 3-position, A.sub.2 is a C.sub.1 -C.sub.3 alkylene group, A.sub.3 is a C.sub.1 -C.sub.4 alkylene group, X is --O-- or --SO.sub.n -- and B is a carboxy group, a C.sub.2 -C.sub.5 alkoxycarbonyl group, a cyano group, an amino group of the formula: ##STR2## or a carbamoyl group of the formula: ##STR3## which is useful as an antiviral agent with no side effect.

REFERENCES:
patent: 3346596 (1967-10-01), Hoch et al.
patent: 3401179 (1968-09-01), Wiese et al.
Tetrahedron Letters, No. 19, pp. 1165-1170, 1964, Moriarty, et al.
Crundwell, et al., Tetrahedron, vol. 34, pp. 1043-1045, 1978.
J. Org. Chem., vol. 41, No. 7, 1976, pp. 1229-1233.
Tetrahedron Letters, No. 46, pp. 4003-4006, 1970.
J. of Org. Chem., vol. 38, No. 10, 1973, pp. 1803-1806.
J.A.C.S., vol. 89, Jul. 19, 1967, pp. 3927-3929.

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