Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1976-04-12
1977-09-20
Drezin, Norman A.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
260295R, 260295AM, 2602955R, 2602955A, C07D21324
Patent
active
040496678
ABSTRACT:
Tricyclic benzodiazepine derivatives ("A") bearing a hydroxylower alkyl substituent in the 1-position and a heterocyclic ring joined between positions 4 and 5 of the benzodiazepine moiety are described. The heterocyclic ring will contain the nitrogen atom appearing at position 4 of the benzodiazepine ring as well as the hetero atom, which may be either oxygen or nitrogen, attached to the carbon atom at the 5-position of the benzodiazepine ring. "A" bearing an oxygen atom in the new heterocyclic ring may be formed from the corresponding 4,5-unsaturated benzodiazepines by treatment with an epoxide compound in the presence of an acid catalyst. "A" bearing either a nitrogen or an oxygen atom in the new heterocyclic ring may be prepared by cyclization of the corresponding open compound. "A" are useful as sedative, muscle relaxant and anti-convulsant agents.
REFERENCES:
patent: 3835149 (1974-09-01), Renfroe
Derieg Michael Edward
Earley James Valentine
Fryer Rodney Ian
Sternbach Leo Henryk
Drezin Norman A.
Hoffman Frank P.
Hoffmann-La Roche Inc.
Leon Bernard S.
Welt Samuel L.
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