Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1996-04-25
1998-05-05
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
540542, 540578, A61K 3155, C07D22300, C07D51302
Patent
active
057474877
ABSTRACT:
Tricyclic compounds of the general Formula I: ##STR1## as defined herein which exhibit antagonist activity at V.sub.1 and/or V.sub.2 receptors and exhibit in viva vasopressin antagonist activity, methods for using such compounds in treating diseases characterized by excess renal reabsorption of water, and processes for preparing such compounds.
REFERENCES:
International Union of Pure and Applied Chemistry (IUPAC), vol. 82, 1960, p. 5566.
Drug Evaluations, 6th Ed., 1986, Amer. Medical Assn., pp. 160-162.
Cecil Textbook of Medicine, 19th Ed., 1992, Wynoaarden, M.D., Editor, pp. 2075-2079.
Yamamura, et al., Science, 252, pp. 572-574, 1991.
Yamamura, et al., Br. J. Pharmacol., 105, pp. 787-791 (1992).
Albright Jay Donald
Reich Marvin Fred
American Cyanamid Company
Coleman Brenda
Eck Steven R.
Shah Mukund J.
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