Tricyclic antidepressant conjugates with antigens and enzymes

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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260112R, 260239D, 424 85, 424 88, 435 4, 435 6, 435 18, 435 19, 435 21, 435 25, 435 26, 435 28, 435188, 435189, 435192, 435195, 514 2, 558230, 558250, 560 38, 562443, 564279, 564367, 564380, 436543, 540590, 530362, 530387, G01N 5300, C12N 996

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046296913

ABSTRACT:
Tricyclic antidepressant functionalized compounds are provided for conjugation through a side chain to antigenic compounds, particularly poly(amino acids), and enzymes. The antigenic conjugates are employed for the production of antibodies and together with the enzyme conjugates find particular use in immunoassays for the determination or detection of the total amount of tricyclic antidepressants present in a sample.

REFERENCES:
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patent: 4258211 (1981-03-01), Engelhardt et al.
patent: 4275160 (1981-06-01), Singh et al.
patent: 4495281 (1985-01-01), Buckler et al.
Ninth New Collegiate Dictionary (Meriam Webster), p. 224.
Aherne et al-Brit. J. Clin. Pharmacol. vol. 3 (1976), pp. 561-565.

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