Tricyclic angiotensin II agonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S359000, C514S351000, C514S383000, C514S385000, C514S408000, C548S250000, C548S255000, C548S300100, C548S400000, C548S452000, C549S083000, C549S200000

Reexamination Certificate

active

08067418

ABSTRACT:
There is provided compounds of formula I,wherein the dotted line, X1, X2, X3, A, Y1, Y2, Y3, Y4, Z1, Z2, R2and R3have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful as selective agonists of the AT2 receptor, and thus, in particular, in the treatment of inter alia gastrointestinal conditions, such as dyspepsia, IBS and MOF, and cardiovascular disorders.

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