Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Reexamination Certificate
2006-04-25
2006-04-25
Wilson, James O. (Department: 1623)
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
C544S248000
Reexamination Certificate
active
07034153
ABSTRACT:
Tri-heterocyclic compound of formula (I)wherein each of W, X and Y is carbon or nitrogen; each of U and Z is CR2, NR13, nitrogen, oxygen, sulfur etc.; A ring is carbocyclic ring, heterocyclic ring; R1is alkyl, alkenyl, alkynyl, NR4R5, OR6etc.; R3is carbocyclic ring, heterocyclic ring;and a pharmaceutically acceptable salt thereof, a process for the preparation thereof, a pharmaceutical comprising them as an active ingredient.A compound of formula (I) is useful, in order to possess corticotropin releasing factor receptor antagonistic activity, for the prevention and/or treatment of depression, anxiety, eating disorder, posttraumatic stress disorder, peptic ulcer, irritable bowl syndrome, Alzheimer's disease, drug addiction or alcohol dependence syndrome etc.
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Kagamiishi Yoshifumi
Nakai Hisao
Johnsen Jason H.
Ono Pharmaceutical Co. Ltd.
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