Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1995-05-25
1998-09-15
Grumbling, Matthew V.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
5142328, 514290, 514254, 514256, 514253, 514325, 514318, 514255, 5142282, 5142358, 514252, 5142278, 514316, 514300, 514312, 514323, 514324, 544361, 544333, 544316, 544238, 544126, 544 586, 544 60, 544295, 544357, 544121, 544360, 544362, 544363, 544379, 544372, 544369, 544370, 544374, 544294, 544 582, 544368, 544373, 544376, 544130, 544365, 546 93, 546203, 546193, 546189, 546123, 546156, 546207, 546206, 546198, 546200, 546201, 546202, C07D40102, C07D40114, C07D40108, C07D40308, A61K 31495, A61K 31505, A61K 3
Patent
active
058078533
ABSTRACT:
A method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells is disclosed. The method comprises the administration of a compound of Formula 1.0: ##STR1## to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being. Novel compounds of formulas 5.0, 5.1 and 5.2, wherein R is --C(R.sup.20)(R.sup.21)(R.sup.46), and 5.3, 5.3A and 5.3B, wherein R is --N(R.sup.25)(R.sup.48), are disclosed. Also disclosed are processes for making 3-substituted compounds of Formulas 5.0, 5.1, 5.2 and 5.3. Further disclosed are novel compounds which are intermediates in the process for making 3-substituted compounds of Formulas 5.0, 5.1, 5.2 and 5.3.
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Bishop W. Robert
Doll Ronald J.
Mallams Alan K.
Njoroge F. George
Petrin Joanne M.
Grumbling Matthew V.
Jeanette Henry C.
Schering Corporation
Thompson Paul
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