Tricyclic amide and urea compounds useful for inhibition of g-pr

Details Tricyclic amide and urea compounds useful for inhibition of g-pr Tricyclic amide and urea compounds useful for inhibition of g-pr

1995-03-24

1998-02-17

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514290, 514253, 514254, 546 93, 544361, 544 582, C07D40108, C07D41714, C07D40114, A61K 31445

Patent

active

057191484

ABSTRACT:
A method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells is disclosed. The method comprises the administration of a compound of Formula 1.0: ##STR1## to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being.
Novel compounds of formulas 5.0, 5.1 and 5.2, wherein R is --C(R.sup.20)(R.sup.21)(R.sup.46), and 5.3, 5.3A and 5.3B, wherein R is --N(R.sup.25)(R.sup.48), are disclosed.
Also disclosed are processes for making 3-substituted compounds of Formulas 5.0, 5.1, 5.2 and 5.3.
Further disclosed are novel compounds which are intermediates in the process for making 3-substituted compounds of Formulas 5.0, 5.1, 5.2 and 5.3.

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