Tricyclic amide and urea compounds useful for inhibition of G-pr

Details Tricyclic amide and urea compounds useful for inhibition of G-pr Tricyclic amide and urea compounds useful for inhibition of G-pr

1995-05-19

1998-09-15

Grumbling, Matthew V.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514290, 546 80, 546 69, 546187, A61K 31535, A61K 31445

Patent

active

058078525

ABSTRACT:
Novel compounds of Formula (7.0a), (7.0b) or (7.0c): ##STR1## are disclosed. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering a compound of the formula (7.0a), (7.0b) or (7.0c) to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being.

REFERENCES:
patent: 4282233 (1981-08-01), Villani
patent: 4826853 (1989-05-01), Piwinski et al.
patent: 4831042 (1989-05-01), Villani
patent: 4863931 (1989-09-01), Schumacher et al.
patent: 5089496 (1992-02-01), Piwinski et al.
patent: 5104876 (1992-04-01), Piwinski et al.
patent: 5141851 (1992-08-01), Brown et al.
patent: 5151423 (1992-09-01), Piwinski et al.
patent: 5393890 (1995-02-01), Syoji et al.
Cell, 65, 1-4 (1991). Month of Publication not provided.
J. Biol. Chem., 266, (24), 15575-15578 (1991) Month of publication not provided.
Proc. Natl. Acad. Sci. USA, 87 3042-3046 (1990) Month of publication not provided.
Proc. Natl. Acad. Sci. USA, 88, 8631-8635 (1991). Month of publication not provided.
Nature, 356. 713-715 (1992) Month of publication not provided.
Proc. Natl. Acad. Sci. USA, 87, 7541-7545 (1990) Month of publication not provided.
J. Biol. Chem. 265, (25) 14701-14704 (1990) Month of publication not provided.
Proc. Natl. Acad. Sci. USA, 87, 7926-7929 (1990) Month of publication not provided.
Cell, 62, 81-88 (1990) Month of publication not provided.
Biochemistry, 31, 3800-3807 Month of publication not provided.
Science, 260, 1934-1937 Month of publication not provided.
Science, 260, 1937-1942 Month of publication not provided.
Piwinski, et al., J. Med. Chem., 34, (1) 457-461 (1991) Month of publication not provided.
Chem. Abstracts No. 21:53129x (1994) for WO94/04561 Month of publication not provided.
Masci, J. Chem. Soc. Chem. Commun., 1262-1263 (1992) Month of publication not provided.
Masci, J. Org. Chem., 50, 4081-4087 (1985) Month of publication not provided.
Sebti, et al., Proc. Ann. Meeting AM Assoc. Cancer Res., 33:A2217 (1992) Month of publication not provided.
Villani, et al., J. Med. Chem., 15, (7) 750-754 (1972) Month of publication not provided.
Billah, et al., Lipids,26, (12) 1172-1174 (1991) Month of publication not provided.
Villani, et al., Arzneim.-Forsch./Drug Res., 36(II), 1311-1314 (1986) Month of publication not provided.

Affiliated with

Also associated with

Rating

Tricyclic amide and urea compounds useful for inhibition of G-pr does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Tricyclic amide and urea compounds useful for inhibition of G-pr, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tricyclic amide and urea compounds useful for inhibition of G-pr will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-87419