Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1994-02-24
1996-04-30
Datlow, Philip I.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514217, 540578, 540580, 540586, C07D22314, C07D491048, C07D49504, A01K 3155
Patent
active
055125620
ABSTRACT:
Tricyclic benzazepines having the general formula ##STR1## wherein A together with the .alpha.- and .beta.-marked carbon atoms is a cyclopentene, cyclohexene, furan, dihydrofuran, pyran, dihydropyran, thiophene, oxazole, pyrrole, pyrroline, tetrahydropyridine or dioxole ring, R.sup.1 is H or alkyl, R.sup.2 and R.sup.3 independently are H, alkoxy, halogen, nitro, cyano or hydroxy, or R.sup.2 and R.sup.3 together may form a furan, dihydrofuran, cyclopentene or dioxole ring and R.sup.4 is H, alkoxy, nitro, cyano, hydroxy or halogen, or a pharmaceutically acceptable salt thereof, are useful in treatment of certain disorders in the central nervous system, e.g., psychosis, pain, depression, sleep disturbances, dyskinesia, Parkinson's disease, stroke.
REFERENCES:
patent: 4255445 (1981-03-01), Brush et al.
patent: 4751222 (1988-06-01), Br.ae butted.strup et al.
Cecil Textbook of Medicine, 19th ed (1992), Wyngaarden, M. D. editor, pp. 2075-2078.
Hohlweg Rolf
Nielsen Erik B.
Agris Cheryl H.
Datlow Philip I.
Novo Nordisk A S
Zelson Steven T.
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