Tricyclic 1,2,4-triazine oxides and compositions for...

Details Tricyclic 1,2,4-triazine oxides and compositions for... Tricyclic 1,2,4-triazine oxides and compositions for...

2011-08-02

2011-08-02

Padmanabhan, Sreeni (Department: 1627)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S218000, C544S183000, C544S184000

Reexamination Certificate

active

07989451

ABSTRACT:
The invention relates to novel tricyclic 1,2,4-triazine-1-oxides and novel tricyclic 1,2,4-triazine-1,4-dioxides of formula Iand to related analogues, to their preparation, and to their use as hypoxia-selective drugs and radiosensitizers for cancer therapy, both alone or in combination with radiation and/or other anticancer drugs.

REFERENCES:
patent: 649 658 (1995-04-01), None
Nagasawa, H., et al; “Design, synthesis and biological activities of antiangiogenic hypoxic cytotoxin, triazine-N-oxide derivatives”;Comparative Biochemistry and Physiology Part A; vol. 132; pp. 33-40 (2002).
Hay, M.P., et al; “Structure-activity relationships of 1,2,4-benzotriazine 1,4-dioxides as hypoxia-selective analogues of Tirapazamine”;J. Med Chem; vol. 46, pp. 169-182 (2003).
Rauth, A.M., et al; “Bioreductive therapies: an overview of drugs and their mechanisms of action”;Int. J. Radiation Oncology Biol Phys; vol. 42, No. 4; pp. 755-762 (1998).

Affiliated with

Also associated with

Rating

Tricyclic 1,2,4-triazine oxides and compositions for... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Tricyclic 1,2,4-triazine oxides and compositions for..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tricyclic 1,2,4-triazine oxides and compositions for... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2736357