Trichothecene conjugates and methods of use

Details Trichothecene conjugates and methods of use Trichothecene conjugates and methods of use

1988-04-28

1990-03-06

Rosen, Sam

Drug, bio-affecting and body treating compositions

Identification or warning feature

Taste or smell or chemical irritation to the eye, nose, or...

424 8591, 424 858, 514 2, 530387, 530388, 530402, A61K 39395

Patent

active

049064525

ABSTRACT:
Conjugates of trichothecenes and agents that bind to a defined population of cells are disclosed. Preferred are conjugates of trichothecene molecules with polyclonal or monoclonal antibodies or fragments thereof that recognize antigens that are present only on tumor cells or are augmented in their expression on tumor cells as compared to normal tissues. Trichothecene molecules are coupled to the agent through non-covalent and covalent linkages, such as peptide bonds, disulfide bonds, thioester bonds, or thioether bonds. Methods for reducing intoxification in a recipient of a trichothecene and an agent and for producing a trichothecene conjugate with improved solubility are also disclosed.

REFERENCES:
patent: 4507234 (1985-03-01), Kato et al.
patent: 4618585 (1986-10-01), Chan
patent: 4624846 (1986-11-01), Goldenberg
patent: 4744981 (1988-05-01), Pa vanasasivam
F. S. Chu et al., Chem. Abstr. 101:228260z (1984).
K. W. Hunter, Jr. et al., Chem. Abstr, 102:76957n (1985).
J. R. Bamburg, Prog. Molec. Subcell, Biol. 8:41-110 (1983).
J. W. Uhr, J. Immunol. 133:i-x (1984).
B. M. J. Foxwell, Immunotoxicology, Academic Press, London, pp. 359-368 (1983).
"Protection Against Trichothecene Mycotoxins", National Academy Press, Washington, D.C., pp. 17-20; 129-136 (1983).

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