Organic compounds -- part of the class 532-570 series – Organic compounds – Imidate esters
Patent
1985-05-28
1987-09-08
Ford, John M.
Organic compounds -- part of the class 532-570 series
Organic compounds
Imidate esters
548240, 548478, 548546, 548547, 549347, 549496, 564209, 564224, 546153, 556420, C07C11918, C07C103127, C07D26102, C07D32100
Patent
active
046925384
ABSTRACT:
New and more efficient chemical processes are provided for preparing (.alpha.S, 5S)-.alpha.-amino-3-chloro-2-isoxazoline-5-acetic acid (AT-125), (.alpha.S, 5S)-.alpha.-amino-3-bromo-2-isoxazoline-5-acetic acid (bromo AT-125) and the C-5 epimers thereof. The disclosed processes allow the above-mentioned antitumor agents to be produced in high yield and purity with substantially fewer steps than prior art chemical procedures.
REFERENCES:
patent: 3856807 (1974-12-01), Hanka et al.
patent: 3878047 (1975-04-01), Hanka et al.
patent: 4225720 (1980-09-01), Martin
patent: 4232164 (1980-11-01), Martin
patent: 4256898 (1981-03-01), Kelly et al.
patent: 4275214 (1981-06-01), Kelly et al.
Baldwin, et al., J. C. S. Chem. Comm., 1976, pp. 795-796.
Hagedorn, et al., Tetrahedron Letters, vol. 21, pp. 229-230.
Silverman, et al., J. Am. Chem. Soc., 1981, 103, 7358-7361.
Beilstein, Handbook of Organic Chemistry, 1(2), 567.
Fiebigs, Ann. Chem., 1980, 703-714.
Chiang Yulin
Doyle Terrence W.
Vyas Dolatrai M.
Bristol-Myers Company
Ford John M.
Morse David M.
Whittenbaugh Robert C.
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