Triazolylphenyl ketone derivatives and production thereof

Details Triazolylphenyl ketone derivatives and production thereof Triazolylphenyl ketone derivatives and production thereof

1977-06-03

1979-06-26

Rollins, Alton D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

260308R, 260326N, 2603265E, 260558H, 42424854, 424263, 424267, 544 82, 544124, 544130, 544131, 544162, 546187, 546193, 546194, 546210, 546275, 546276, 560350, C07D24910, C07D40106, C07D40110, C07D41306

Patent

active

041593740

ABSTRACT:
Triazolyl ketone derivatives of the formula: ##STR1## (wherein R represents lower alkoxy or the group ##STR2## R.sup.4 and R.sup.5 each represents hydrogen, lower alkyl, ##STR3## represents hetero ring selected from pyrrolidino, piperidino, and morpholino; R.sup.1 represents halogen or nitro; R.sup.2 represents hydrogen or lower alkyl; R.sup.3 represents lower alkyl, phenyl, or the group ##STR4## R.sup.6 represents hydrogen, lower alkyl, or benzyl; R.sup.7 and R.sup.8 each represents hydrogen, lower alkyl, or ##STR5## represents hetero ring selected from pyrrolidino, piperidino, and morpholino; and Ar represents phenyl, o-halogenophenyl, or 2-pyridyl) and their pharmaceutically acceptable acid addition salts, being useful as anxiolytics, hypnotics, anticonvulsants, muscle relaxants, or their synthetic intermediates, are prepared by several routes.

REFERENCES:
patent: 3862171 (1975-01-01), Gagneux et al.
patent: 3870714 (1975-03-01), Gagneux et al.
patent: 3993660 (1976-11-01), Hester
patent: 4007219 (1977-02-01), Hassall et al.

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