Triazolopyridazine protein kinase modulators

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C435S184000, C514S248000, C514S184000, C514S243000, C544S118000, C544S236000

Reexamination Certificate

active

08071581

ABSTRACT:
The present disclosure relates to triazolopyridazine protein kinase modulators of Formula (I), methods of using these compounds to treat diseases mediated by kinase activity.

REFERENCES:
patent: WO 02/083139 (2002-10-01), None
patent: WO 02/083675 (2002-10-01), None
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Target et al “Synthetic inhibitors of interleukin-6 II: 3,5-diaryl pyridines and meta-terphenyls”, Biorganic & Medicinal Chemistry Letters, vol. 5, No. 18, pp. 2143-2146, 1995.
Schafer et al. Drug Discovery Today 2008, 13 (21/22), 913-916.
Horig et al. Journal of Translational Medicine 2004, 2(44).
Sawyer et al “Synthesis and activity of New Aryl- and heteroaryl-substituted pyrazole inhibitors of the transforming growth factor-β type I receptor kinase domain”. Journal of Medicinal Chemistry, vol. 46, No. 19, Sep. 11, 2003.
Wolff Burgers Medicinal Chemistry and Drug Discovery, Fifth Edition, vol. I: Principles and Practice, Wiley-Interscience 1995, pp. 974-977.

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