Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Reexamination Certificate
2007-03-22
2010-10-19
Chung, Susannah (Department: 1626)
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
C546S184000, C548S255000, C548S262200, C548S356100, C548S300100, C548S400000
Reexamination Certificate
active
07816522
ABSTRACT:
A Compound represented by the following general formula (1), salts thereof or hydrates of the foregoing is a novel compound useful for treatment and/or prevention of diseases associated with thrombus formation, and which is safer with suitable physicochemical stability.[wherein R1a, R1b, R1cand R1deach independently represent hydrogen, etc.; R2represents optionally substituted phenyl, etc.; R3represents optionally substituted C6-10 aryl, etc.; and Z1and Z2each independently represent hydrogen]
REFERENCES:
patent: 6916837 (2005-07-01), Satoh et al.
patent: 7576098 (2009-08-01), Glunz et al.
patent: 2002/0004608 (2002-01-01), Alig et al.
patent: 2002/0052417 (2002-05-01), Klingler et al.
patent: 2003/0181766 (2003-09-01), Satoh et al.
patent: 2004/0242627 (2004-12-01), Suzuki et al.
patent: 2004/0254376 (2004-12-01), Suzuki et al.
patent: 2005/0004197 (2005-01-01), Suzuki et al.
patent: 2005/0004204 (2005-01-01), Suzuki et al.
patent: 2005/0245592 (2005-11-01), Suzuki et al.
patent: 2008/0015199 (2008-01-01), Clark et al.
patent: 2008/0132507 (2008-06-01), Clark et al.
patent: 2009/0270433 (2009-10-01), Clark et al.
patent: 58281/80 (1980-11-01), None
patent: 0 019 586 (1980-11-01), None
patent: 1 020 434 (2000-07-01), None
patent: 1 078 917 (2001-02-01), None
patent: 1 312 602 (2003-05-01), None
patent: 1 828 152 (2007-09-01), None
patent: 2002-509924 (2002-04-01), None
patent: 2002-543176 (2002-12-01), None
patent: 2003-212837 (2003-07-01), None
patent: 2003-534311 (2003-11-01), None
patent: 2003-535844 (2003-12-01), None
patent: 1512055 (1992-07-01), None
patent: WO-99/10316 (1999-03-01), None
patent: WO-99/41231 (1999-08-01), None
patent: WO-99/50255 (1999-10-01), None
patent: WO-00/35858 (2000-06-01), None
patent: WO-00/41531 (2000-07-01), None
patent: WO-00/58346 (2000-10-01), None
patent: WO 00/58346 (2000-10-01), None
patent: WO-00/66545 (2000-11-01), None
patent: WO-02/085855 (2002-10-01), None
patent: WO-2004/032846 (2004-04-01), None
patent: WO-2004/101555 (2004-11-01), None
patent: WO-2006/041119 (2006-04-01), None
patent: WO-2006/062972 (2006-06-01), None
patent: WO 2007/111212 (2007-10-01), None
Roussel et al., “Inhibition of the Tissue Factor/Factor VIIa Complex—Lead Optimisation Using Combinatorial Chemistry,” Tetrahedron, vol. 55, pp. 6219-6230 (1999).
Database WPI Week 199323, Thomson Scientific, London, GB 1993-186830, XP002540626.
Vippagunta et al., “Crystalline Solids,”Adv. Drug Delivery Rev., 48, pp. 3-26 (2001).
McMahon et al., “VEGF Receptor Signaling in Tumor Angiogenesis,”The Oncologist, 5 (suppl 1): pp. 3-10 (2000).
Fu et al., “Anti-apoptotic role . . . ,”Biochemical and Biophysical Research Comm., 349, pp. 504-512 (2006).
Pinedo et al., “Translational Research . . . ,”The Oncologist, 5 (suppl 1): pp. 1-2 (2000).
Office Action of Jun. 24, 2009 in U.S. Appl. No. 11/665,385.
“Cancer.” Medline Plus. (2009). Accessed Mar. 17, 2009. <http://www.nlm.nih.gov/medlineplus/cancer.html>.
Golub et al. “Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring.” Science (1999), vol. 286, 521-537.
Lala et al. “Role of nitric oxide in tumor progression: Lessons form experimental tumors.” Cancer and Metastasis Reviews (1998), 17(1), 91-106.
Notice of Allowance of Feb. 23, 2010 in U.S. Appl. No. 11/665,385.
Notice of Allowance of Feb. 23, 2010 in U.S. Appl. No. 12/234,116.
International Preliminary Report on Patentability (Forms PCT/IB/338 and PCT/IB/373) and Written Opinion of the International Searching Authority (Form PCT/ISA/327) issued Apr. 15, 2010, in International Application No. PCT/JP2008/066944.
Azuma Hiroshi
Clark Richard
Hirota Shinsuke
Horizoe Tatsuo
Inoue Atsushi
Birch & Stewart Kolasch & Birch, LLP
Chung Susannah
Eisai Co. Ltd.
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