Triazolo-benzodiazepine-1-ethanamines as diuretics

Details Triazolo-benzodiazepine-1-ethanamines as diuretics Triazolo-benzodiazepine-1-ethanamines as diuretics

1985-01-31

1987-08-25

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

540563, C07D48704

Patent

active

046894136

ABSTRACT:
Triazolo-benzodiazepine-1-ethanamines of the formulas ##STR1## where R, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and Ring A are as defined in the specification, e.g., 8-chloro-N,N-dimethyl-.beta.,6-diphenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benz odiazepine-1-ethanamine, and pharmacologically acceptable salts thereof, have been found to have substantial diuretic, natriuretic, but little, if any, kaliuretic activity, which can be used alone, or concomittently with other diuretic drugs such as furosemide or hydrochlorothiazide and/or with antihypertensive agents such as propranolol, captopril, minoxidil, prazosin, guanadrel sulfate, whose actions are supplemented by the action of a diuretic drug.

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Roseberry et al., Biometrics, vol. 20, (1964), pp. 73-84.

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