Triazolo [3,4-b]pyridazines, process for their preparation and p

Details Triazolo [3,4-b]pyridazines, process for their preparation and p Triazolo [3,4-b]pyridazines, process for their preparation and p

1987-06-10

1989-03-07

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544236, 544224, 544239, 549323, 549549, C07D48704, A61K 3150

Patent

active

048107050

ABSTRACT:
The invention relates to 1,2,4-triazolo [4,3-b]pyridazines substituted in the 7-position of formula: ##STR1## in which R represents hydrogen, a lower alkyl group, a phenyl group, a chlorophenyl group or a benzyl group and R.sub.1 represents a phenyl, halogenophenyl, trifluoromethylphenyl, lower alkyl-phenyl or lower alkoxy-phenyl group or a phenyl-lower alkyl group, or one of its pharmaceutically acceptable salts.
Said compounds antagonize the effects of benzodiazepines and therefore are useful as antidotes in the abuse of benzodiazepines and compounds acting on benzodiazepine receptors.

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