Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-01-16
2000-11-28
Bernhardt, Emily
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
51425405, 51425407, 544366, 544369, A61K 31496, C07D40310, C07D40314
Patent
active
061536164
ABSTRACT:
A compound of formula I, or an optical isomer or pharmaceutically acceptable salt thereof, ##STR1## is disclosed as well as a pharmaceutical composition and a method of treating or preventing a fungal infection using the compound.
REFERENCES:
patent: 4503063 (1985-03-01), Richardson et al.
patent: 4738962 (1988-04-01), Holmwood et al.
patent: 4885294 (1989-12-01), Ray et al.
patent: 5047548 (1991-09-01), Richardson et al.
patent: 5545652 (1996-08-01), Itoh et al.
Tasaka et al.; "Optically Active Antifungal Azoles. I. Synthesis and Antifungal Activity of (2R,3R)-2-(2,4-Difluorophenyl)-3-mercapto-1-(1H-1,2,4-triazol-1-yl)-2-buta nol and Its Stereoisomers"; Jun. 1993; Chem. Pharm. Bull. 41(6) 1035-1042 (1993).
Naito et al.; ER-30346 "Triazole Antifungal"; Drugs of the Future 1996, 21(1):20-24.
Fromtling et al.; SCH 51048 "Antifungal"; Drugs of the Future 1995, 20(3): 241-247.
Fromtling et al.; SCH-56532 "Antifungal"; Drugs of the Future 1996, 21(2): 160-166.
Fromtling et al.; UK-109496 "Voriconazole"; "Antifungal"; Drugs of the Future 1996, 21(3): 266-271.
Itoh et al.; "TAK-187, a New Antifungal Triazole: Synthesis and Antifungal Activity"; 36th ICAAC, Sep. 15-18, 1996, New Orleans, Louisiana.
Heeres et al.; "Antimycotic Azoles. 7. Synthesis and Antifungal Properties of a Series of Novel Triazol-3-ones"; J. Med. Chem. 1984, 27, 894-900.
Saksena et al; "SCH 51048, A Novel Broad-Spectrum Orally Active Antifungal Agent: Synthesis and Preliminary Structure-Activity Profile"; Bioorganic & Medicinal Chemistry Letters, vol. 5, No. 2, pp. 127-132, 1995.
Ogura et al.; Abstract; "KP-103, a Novel Topical Antifungal Triazole: Structure-Activity Relationships of Azolylamine Derivatives"; 36th Interscience Conference on Antimicrobial Agents and Chemotherapy, New Orleans, Louisiana; Poster session: Sep. 15-18, 1996.
"Solution Phase Combinatorial Synthesis of Arylpiperazines", Neuville, et al.; Tetrahedron Letters, vol. 38. No. 23, pp. 4091-4094, 1997.
Zhang et al, Chemical Abstracts, vol. 119, No. 139186 (1993).
Abel Mark
Bathini Yadagiri
Daneshtalab Mohsen
Furukawa Tetsuo
Ha Chan
Bernhardt Emily
SynPhar Laboratories, Inc.
Taiho Pharmaceuticals Co., Ltd.
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