Triazole derivatives of fenamates as antiinflammatory agents

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514383, 5482626, 5482632, 5482648, 5482654, 5482656, 5482668, 5482672, 5482678, 5482686, A61K 3141, C07D24912, C07D24914

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active

049621190

ABSTRACT:
The present invention is novel compounds which are 1,2,4-triazoles, derivatives of fenamates and pharmaceutically acceptable additions and base salts thereof, pharmaceutical compositions and methods of use thereof. The invention compounds are now found to have activity as inhibitors of 5-lipoxygenase and/or cyclooxygenase providing treatment of conditions advantageously affected by such inhibition including inflammation, arthritis, pain, fever, and the like.

REFERENCES:
patent: 4618617 (1986-10-01), Yamamoto
Chemical Abstracts--J6 1005-072-A Sumitomo Chem Ind KK.
Legrand et al., "Heterocyclic Sulfur Compounds, etc." CA 84:17262u (1976).

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