Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1989-06-09
1990-10-09
Hollrah, Glennon H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514383, 5482626, 5482632, 5482648, 5482654, 5482656, 5482668, 5482672, 5482678, 5482686, A61K 3141, C07D24912, C07D24914
Patent
active
049621190
ABSTRACT:
The present invention is novel compounds which are 1,2,4-triazoles, derivatives of fenamates and pharmaceutically acceptable additions and base salts thereof, pharmaceutical compositions and methods of use thereof. The invention compounds are now found to have activity as inhibitors of 5-lipoxygenase and/or cyclooxygenase providing treatment of conditions advantageously affected by such inhibition including inflammation, arthritis, pain, fever, and the like.
REFERENCES:
patent: 4618617 (1986-10-01), Yamamoto
Chemical Abstracts--J6 1005-072-A Sumitomo Chem Ind KK.
Legrand et al., "Heterocyclic Sulfur Compounds, etc." CA 84:17262u (1976).
Boschelli Diane H.
Connor David T.
Flynn Daniel L.
Hoefle Milton L.
Sircar Jagadish C.
Hollrah Glennon H.
Morris Patricia L.
Thierstein Joan
Warner-Lambert & Company
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