Triazole derivatives for use as antimycotic agents

Details Triazole derivatives for use as antimycotic agents Triazole derivatives for use as antimycotic agents

1987-12-23

1989-03-14

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548262, 546276, 514383, C07D24908, C07D40100, A61K 3141

Patent

active

048124656

ABSTRACT:
Imidazole and triazole derivatives of the general formula ##STR1## in which Ar denotes thienyl or denotes phenyl, biphenylyl or naphthyl, each of which is substituted by halogen, lower alkyl or lower alkoxy, R.sub.1 denotes hydrogen or lower alkyl, Alk denotes straight-chain or branched alkyl having 1 to 10 carbon atoms, Y denotes oxygen, sulfur, sulfinyl or sulfonyl, n denotes zero, 1 or 2, Z denotes oxygen, sulfur or sulfinyl, m denotes zero or 1, R.sub.3 denotes hydrogen, straight-chain or branched alkyl, cyclohexyl, or denotes phenyl which is optionally substituted by hydroxyl, halogen, trifluoromethyl, lower alkyl or lower alkoxy, or denotes biphenlyl, pyridyl or denotes naphthyl which is optionally substituted by halogen, X denotes CH or N, and R.sub.2 denotes hydrogen or lower alkyl, and their pharmaceutically acceptable acid addition salts for use as antimycotic agents in human and veterinary medicine.

REFERENCES:
patent: 4559077 (1985-12-01), Regel et al.
H. Buchel, "The History of Azole Chemistry", 1986, pp. 11-23.
G. Jager, "The Chemistry of N-Substituted Azole Fungicides", 1983, pp. 55-65.
Godefroi et al., J. Med. Chem. 1969, pp. 784-791.

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