Triazole derivatives as tachykinin receptor antagonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C548S255000

Reexamination Certificate

active

07320994

ABSTRACT:
This application relates to a compound of Formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions thereof, and its use as an inhibitor of the NK-1 subtype of tachykinin receptors, as well as a process for its preparation and intermediates therefor. (I) wherein: D is a C1-C3alkane-diyl; R1is phenyl, which is optionally substituted with one to three substitutents independently selected from the group consisting of halo, C1-C4alkyl, C1-C4alkoxy, cyano, difluoromethyl, trifluoromethyl, and trifluoromethoxy; R4is a radical selected from the group consisting of: (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH)

REFERENCES:
patent: 5998444 (1999-12-01), Russell
patent: 6060478 (2000-05-01), Gilligan et al.
patent: 6407106 (2002-06-01), Jasserand et al.
patent: 7179804 (2007-02-01), Amegadzie et al.
patent: 0 699 665 (1996-03-01), None
patent: 0 699 665 (2003-05-01), None
patent: 2 329 275 (1976-10-01), None
patent: P2002-123925 (2002-04-01), None
patent: WO 95/11880 (1995-05-01), None
patent: WO 97/40025 (1997-10-01), None
patent: WO 98/03510 (1998-01-01), None
patent: WO 99/07677 (1999-02-01), None
patent: WO 01/44200 (2001-06-01), None
patent: WO 02/08232 (2003-01-01), None
Duffy et al., Correlation of NK-1 receptor occupancy in gerbil striatum with behavorial effects of NK1 antagonists, J. Pharm. And Ex. Th., vol. 301, No. 2, 2002, especially pp. 536-542.
L'Abbé, et al., “Synthesis and Thermolysis of 4-Substituted 5-Azido-1-Phenyl-1,2,3- Triazoles”,Tetrahedron, 44:12, pp. 3617-3626 (1988).
Hajjaji, et al., “Synthesis and Evaluation of the Inhibitor Effect of a New Class of Triazole Compounds,”Progress in Organic Coatings, 38, pp. 207-212 (2000).
Abu-Orabi, et al., “Dipolar Cycloaddition Reactions of Organic Azides,”J. Heterocyclic Chem., 26, pp. 1461-1468 (1989).
Theocharis, et al., “Synthesis and Spectral Data of 4,5-Bix[5-aryl-1,3,4- oxadiazol-2-yl]-1-benzyl-1,2,3-triazoles,”J. Heterocyclic Chem, 27, pp. 1685-1688 (1990).
Al-Talib, et al., “Synthesis of 4,5-Bis-[5-aryl-1,3,4-oxadiazol-2-YL]-1-Substgituted Benzyl-1,2,3-Triazoles,”Indian J. of Heterocyclic Chem., 8, pp. 183-188 (1999).
Cottrell, “An Improved Procedure for the Preparation of 1-Benzyl-1H-1,2,3- triazoles from Benzyl Azides,”J. Heterocyclic Chem., 28, pp. 301-304 (1990).
ACS Chemcats 2001:1613994, Publication Date Jan. 7, 2001, Order No. AN-666/14744011, CAS Registry No. 354780-46-4.
Biagi, et al., “N<6>-Cycloalkyl-2-Phenyl-3-Deaza-8-Azaad Nines: A New Class of A1 Adenosine Receptor Ligands. A Comparison With the Corresponding Adenines and 8-Azaadenines”,European J. of Medicinal Chemistry, 38, pp. 983-990 (2003).
Ivanov, et al., “Synthesis of 1,2,3-Triazolo '5,4-e!-1,4-diazepine”,J. of Organic Chemistry of the USSR, XP009037402, 25:9, pp. 1785-1789 (1989).
Katritzky, et al., “Synthesis of C-Carbamoyl-1,2,3-triazoles by Microwave-Induced 1,3-Dipolar Cycloaddition of Organic Azides to Acetylenic Amides”,J. Organ. Chem., XP002299474, 67, pp. 9077-9079 (2002).
Katritzky, et al., “1,3-Dipolar Cycloadditions of Organic Azides to Ester or Benzotriazolylcarbonyl Activated Acetylenic Amides”,ARKIVOC, 15, XP002299475, 15, pp. 47-64 (2003).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Triazole derivatives as tachykinin receptor antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Triazole derivatives as tachykinin receptor antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Triazole derivatives as tachykinin receptor antagonists will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2799272

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.