Triazole derivatives as tachykinin receptor antagonists

Details Triazole derivatives as tachykinin receptor antagonists Triazole derivatives as tachykinin receptor antagonists

2008-01-22

2008-01-22

Anderson, Rebecca (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S255000

Reexamination Certificate

active

07320994

ABSTRACT:
This application relates to a compound of Formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions thereof, and its use as an inhibitor of the NK-1 subtype of tachykinin receptors, as well as a process for its preparation and intermediates therefor. (I) wherein: D is a C1-C3alkane-diyl; R1is phenyl, which is optionally substituted with one to three substitutents independently selected from the group consisting of halo, C1-C4alkyl, C1-C4alkoxy, cyano, difluoromethyl, trifluoromethyl, and trifluoromethoxy; R4is a radical selected from the group consisting of: (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH)

REFERENCES:
patent: 5998444 (1999-12-01), Russell
patent: 6060478 (2000-05-01), Gilligan et al.
patent: 6407106 (2002-06-01), Jasserand et al.
patent: 7179804 (2007-02-01), Amegadzie et al.
patent: 0 699 665 (1996-03-01), None
patent: 0 699 665 (2003-05-01), None
patent: 2 329 275 (1976-10-01), None
patent: P2002-123925 (2002-04-01), None
patent: WO 95/11880 (1995-05-01), None
patent: WO 97/40025 (1997-10-01), None
patent: WO 98/03510 (1998-01-01), None
patent: WO 99/07677 (1999-02-01), None
patent: WO 01/44200 (2001-06-01), None
patent: WO 02/08232 (2003-01-01), None
Duffy et al., Correlation of NK-1 receptor occupancy in gerbil striatum with behavorial effects of NK1 antagonists, J. Pharm. And Ex. Th., vol. 301, No. 2, 2002, especially pp. 536-542.
L'Abbé, et al., “Synthesis and Thermolysis of 4-Substituted 5-Azido-1-Phenyl-1,2,3- Triazoles”,Tetrahedron, 44:12, pp. 3617-3626 (1988).
Hajjaji, et al., “Synthesis and Evaluation of the Inhibitor Effect of a New Class of Triazole Compounds,”Progress in Organic Coatings, 38, pp. 207-212 (2000).
Abu-Orabi, et al., “Dipolar Cycloaddition Reactions of Organic Azides,”J. Heterocyclic Chem., 26, pp. 1461-1468 (1989).
Theocharis, et al., “Synthesis and Spectral Data of 4,5-Bix[5-aryl-1,3,4- oxadiazol-2-yl]-1-benzyl-1,2,3-triazoles,”J. Heterocyclic Chem, 27, pp. 1685-1688 (1990).
Al-Talib, et al., “Synthesis of 4,5-Bis-[5-aryl-1,3,4-oxadiazol-2-YL]-1-Substgituted Benzyl-1,2,3-Triazoles,”Indian J. of Heterocyclic Chem., 8, pp. 183-188 (1999).
Cottrell, “An Improved Procedure for the Preparation of 1-Benzyl-1H-1,2,3- triazoles from Benzyl Azides,”J. Heterocyclic Chem., 28, pp. 301-304 (1990).
ACS Chemcats 2001:1613994, Publication Date Jan. 7, 2001, Order No. AN-666/14744011, CAS Registry No. 354780-46-4.
Biagi, et al., “N<6>-Cycloalkyl-2-Phenyl-3-Deaza-8-Azaad Nines: A New Class of A1 Adenosine Receptor Ligands. A Comparison With the Corresponding Adenines and 8-Azaadenines”,European J. of Medicinal Chemistry, 38, pp. 983-990 (2003).
Ivanov, et al., “Synthesis of 1,2,3-Triazolo '5,4-e!-1,4-diazepine”,J. of Organic Chemistry of the USSR, XP009037402, 25:9, pp. 1785-1789 (1989).
Katritzky, et al., “Synthesis of C-Carbamoyl-1,2,3-triazoles by Microwave-Induced 1,3-Dipolar Cycloaddition of Organic Azides to Acetylenic Amides”,J. Organ. Chem., XP002299474, 67, pp. 9077-9079 (2002).
Katritzky, et al., “1,3-Dipolar Cycloadditions of Organic Azides to Ester or Benzotriazolylcarbonyl Activated Acetylenic Amides”,ARKIVOC, 15, XP002299475, 15, pp. 47-64 (2003).

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