Triazole derivatives and salts thereof and antifungal agent cont

Details Triazole derivatives and salts thereof and antifungal agent cont Triazole derivatives and salts thereof and antifungal agent cont

1992-12-08

1994-11-22

Morris, Patricia L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5482674, 5482676, 5482686, A01N 43653, C07D24908

Patent

active

053669894

ABSTRACT:
The present invention relates to a compound represented by the general formula (1) or its salt, a process for producing the same, and an antifungal agent comprising the same as an effective component: ##STR1## wherein R.sup.1 represents a substituted or unsubstituted aryl group or a substituted or unsubstituted heterocyclic group bonded through a carbon atom in the ring to the main chain; R.sup.2 presents a hydrogen atom, a fluorine atom or a substituted or unsubstituted alkyl group; and R.sup.3 represents a cyano group, a thioamido group or a group represented by the formula ##STR2## in which R.sup.4 is a hydroxyl group or a group of the formula ##STR3## (R.sup.7 and R.sup.8, which may be the same or different, are hydrogen atoms or substituted or unsubstituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, amino, alkoxy, hydroxyl or heterocyclic groups, and may form a substituted or unsubstituted heterocyclic group together with the nitrogen atom to which R.sup.7 and R.sup.8 attach), R.sup.5 is a substituted or unsubstituted alkoxy group or a group of the formula ##STR4## (R.sup.7 and R.sup.8 are as defined above), and R.sup.6 is a hydrogen atom or a substituted or unsubstituted alkyl group.

REFERENCES:
patent: 4503063 (1985-03-01), Richardson et al.
patent: 4518604 (1985-05-01), Richardson et al.
patent: 4616026 (1986-10-01), Richardson et al.
patent: 4616027 (1986-10-01), Richardson et al.
patent: 4960782 (1990-10-01), Gymer et al.
patent: 5047548 (1991-09-01), Richardson et al.
Burger, "Medicinal Chemistry", 2nd Ed. NY 1960, p. 1055.

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