Triazole derivatives

Details Triazole derivatives Triazole derivatives

2005-08-09

2005-08-09

Morris, Patricia L. (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S264200, C548S264400

Reexamination Certificate

active

06927230

ABSTRACT:
A compound of the formula (I):wherein R1is lower alkyl which is optionally substituted withhalogen, cyano,N,N-di(lower)alkylcarbamoyl,phenyl optionally substituted with halogen, or heterocyclic group,cyclo(lower)alkyl,lower alkynyl, orN,N-di(lower)alkylcarbamoyl;R2is lower alkyl, lower alkoxy, cyano, or 1H-pyrrol-1-yl;R3is lower alkyl, lower alkoxy, or cyano;X is O, S, SO or SO2;Y and Z are each CH or N; andm is 0 or 1;or salts thereof, which are useful as a medicament.

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Geza Szilagyi et al.; “Preparation and antiarthritic activity of new 1,5-diaryl-3-(alkylthio)-1H 1,2,4-triazoles and corresponding sulfoxides and sulfones” European Journal of Medicinal Chemistry, vol. 25, No. 2, pp. 95-101, 1990.
L. Czollner et al.: “1,2,4-triazoles, II 1 synthesis of 1,5-diphenyl-3-trifluoromethl-1H-1,2,4-triazoles” Monatshefte Fur Chemie, vol. 119, pp. 349-353 1988.

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