Triazole containing diphosphonate compounds and the use thereof

Details Triazole containing diphosphonate compounds and the use thereof Triazole containing diphosphonate compounds and the use thereof

1987-07-23

1988-11-15

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

548119, 548112, 548113, 548115, 514 80, 514 89, 514 92, 514 94, 546 22, A61K 3141, C07F 965

Patent

active

047849932

ABSTRACT:
The present invention provides diphosphonates of the general formula: ##STR1## wherein Het is 1,2,3-triazole, or 1,2,4-triazole radical, which is optionally substituted by alkyl, alkoxy, halogen, hydroxyl, carboxyl, an amino group optionally substituted by alkyl or acyl radicals or is a benzyl radical optionally substituted by alkyl, nitro, amino or aminoalkyl, A is a straight-chained or branched, saturated or unsaturated hydrocarbon chain containing 2 to 8 carbon atoms, X is a hydrogen atom, optionally substituted by acyl, or an amino group optionally substituted by alkyl or acyl radicals and R is a hydrogen atom or an alkyl radical; and the pharmacologically acceptable salts thereof.
The present invention also provides processes for the preparation of these diphosphonates and pharmaceutical compositions containing them.

REFERENCES:
patent: 4503049 (1985-03-01), Bierre et al.
patent: 4687767 (1987-08-01), Bosies et al.

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