Triazole compounds useful as protein kinase inhibitors

Details Triazole compounds useful as protein kinase inhibitors Triazole compounds useful as protein kinase inhibitors

2006-10-03

2006-10-03

McKenzie, Thomas C. (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

C544S255000, C544S256000, C544S258000, C544S277000, C544S278000, C544S279000, C544S280000, C544S284000, C514S249000, C514S260100, C514S261100, C514S262100, C514S263200, C514S265100, C514S266230, C514S264110

Reexamination Certificate

active

07115739

ABSTRACT:
This invention describes novel triazole compounds of formula IX:wherein Z1is nitrogen or CR9and Z2is nitrogen or CH, provided that at least one of Z1and Z2is nitrogen; G is Ring C or Ring D; Ring C is selected from a phenyl, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, or 1,2,4-triazinyl ring, wherein said Ring C has one or two ortho substituents independently selected from —R1; Ring D is a 5–7 membered monocyclic ring or 8–10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; Rxand Ryare independently selected from T-R3, or Rxand Ryare taken together with their intervening atoms to form a fused ring; R1, R3, and T are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of GSK-3 and Aurora, for treating diseases such as diabetes, cancer, and Alzheimer's disease.

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