Triazole compounds and antifungal compositions thereof

Details Triazole compounds and antifungal compositions thereof Triazole compounds and antifungal compositions thereof

1994-04-22

1995-04-11

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5482686, A61K 3141, C07D40312

Patent

active

054058619

ABSTRACT:
The novel 2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-propanol derivertives of the formula (I): ##STR1## wherein, R.sup.0, R.sup.1 and R.sup.2 are the same or different and represent a hydrogen atom or a lower alkyl group; A represents a formula: ##STR2## wherein, X stands for a chemical bond or a formula: ##STR3## (wherein, X' stands for a chemical bond or an alkylene group having 1 to 5 carbon atoms which may contain sulfur or oxygen atom as the constituent atoms, R.sup.5 and R.sup.6 are the same or different and stand for a hydrogen atom or a lower alkyl group), R.sup.3 stands for an aromatic heterocyclic group which may be substituted, n denotes 0, 1 or 2), and R.sup.4 stands for a hydrogen atom or an alkanoyl group, or a physiologically acceptable salt thereof have antifungal activities, and they are used for preventing or treating infectious diseases caused by fungi.

REFERENCES:
patent: 4505919 (1985-03-01), Cooper et al.
patent: 4678789 (1987-07-01), Richardson et al.

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