Triazole and imidazole compounds and their use as antifungal the

Details Triazole and imidazole compounds and their use as antifungal the Triazole and imidazole compounds and their use as antifungal the

1994-09-23

1996-08-13

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514252, 514397, 544366, 5482678, 5483137, A61K 3141, A61K 31415, C07D24908, C07D40310

Patent

active

055456529

ABSTRACT:
The present invention provides an azole compound represented by the formula (I): ##STR1## wherein Ar is an optionally-substituted phenyl group; R.sup.1 and R.sup.2 are, the same or different, a hydrogen atom or a lower alkyl group, or R.sup.1 and R.sup.2 may combine together to form a lower alkylene group; R.sup.3 is a hydrogen atom or an acyl group; Y is a nitrogen atom or a methine group; and A is an optionally-substituted saturated cyclic amide group bonded through a first nitrogen atom, or a salt thereof, which is useful for prevention and therapy of fungal infections of mammals as antifungal agent.

REFERENCES:
patent: 4753957 (1988-06-01), Chan
patent: 5371101 (1994-12-01), Itoh et al.
Konosu et al., "Triazole Antifungals, IV. Synthesis And Antifungal Activities Of 3-Acylamino-2-aryl-2-butanol Derivatives", Chem. Pharm. Bull., vol. 39(10):2581-2589, Oct. (1991).

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