Triazine derivatives as universal peptide isotope tag...

Details Triazine derivatives as universal peptide isotope tag... Triazine derivatives as universal peptide isotope tag...

2002-12-13

2008-09-16

Warden, Jill (Department: 1797)

Chemistry: analytical and immunological testing

Peptide, protein or amino acid

C544S209000, C514S245000

Reexamination Certificate

active

07425451

ABSTRACT:
Compounds, compositions, methods for sequencing proteins and peptides, and methods for identifying proteins and peptides in a mixture, are disclosed. Compounds of formula A-B-C wherein A is a nucleophilic reactive group, B is a detectable moiety capable of being isotopically labeled, and C is a charge replacement group, are used to label the peptides at the N-terminus or the C-terminus. The tagged peptides can then be analyzed by mass spectroscopy.

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