Triazine derivatives

Details Triazine derivatives Triazine derivatives

1979-05-07

1981-03-03

Ford, John M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544211, 544212, C07D25146, A61K 3153, C07D40104, C07D40106

Patent

active

042541220

ABSTRACT:
The invention concerns new analgesic 6-acylaminotetrahydro-1,3,5-triazine-2,4-dione derivatives of the formula: ##STR1## in which R.sup.1 is an optionally substituted phenyl, phenyl- (1-4C)alkyl, naphthyl, monocyclic or bicyclic heteroaromatic or (monocyclic or bicyclic heteroaromatic)- (1-4C)alkyl radical, R.sup.2 is a (3-8C)cycloalkyl, [(3-8C)cycloalkyl]-(1-4C)alkyl or (3-6C)alkenyl radical, or an optionally substituted phenyl or phenyl- (1-4C)alkyl radical, and R.sup.3 is a (1-4C)alkyl radical, preferably a methyl radical; together with pharmaceutically acceptable salts thereof. Also provided are processes for the manufacture of, and pharmaceutical compositions of, derivatives of formula I and salts thereof. Some of the derivatives of formula I possess anti-inflammatory properties and/or are inhibitors of the enzyme prostaglandin synthetase in addition to possessing analgesic properties.
A typical compound of the invention is 3-(thien-2-yl)-6-[(N-acetyl)isobutylamino]tetrahydro-1,3,5-triazine-2,4-di one.

REFERENCES:
patent: 4035365 (1977-07-01), Kay
patent: 4082536 (1978-04-01), Kay
patent: 4105433 (1978-08-01), Collins et al.
patent: 4156002 (1979-05-01), Brown et al.

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