Triazine compounds

Details Triazine compounds Triazine compounds

2006-05-16

2006-05-16

Balasubramanian, Venkataraman (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S231500, C514S241000, C544S197000, C544S198000, C544S206000, C544S207000, C544S219000, C544S111000, C544S059000

Reexamination Certificate

active

07045517

ABSTRACT:
This invention relates to triazine compounds of formula (I):R1is , aryl,or heteroaryl; each of R2, R4, and R5, independently, is Rc, halogen, nitro, nitroso, cyano, azide, isothionitro, SRc, or ORc; R3is Rc, alkenyl, alkynyl, aryl, heteroaryl, cyclyl, heterocyclyl, ORc, OC(O)Rc, SO2Rc, S(O)Rc, S(O2)NRcRd, SRc, NRcRd, NRcCORd, NRcC(O)ORd, NRcC(O)NRcRd, NRcSO2Rd, CORc, C(O)ORc, or C(O)NRcRd; n is 0, 1, 2, 3, 4, 5, 6, or 7; X is O, S, S(O), S(O2), or NRc; Y is a covalent bond, CH2, C(O), C═N—Rc, C═N—ORc, C═N—SRc, O, S, S(O), or S(O2); Z is N; and W is O, S, S(O), S(O2), NRC, or NC(O)Rc; in which each of Raand Rb, independently, is H, alkyl, aryl, heteroaryl; and each of Rcand Rd, independently, is H, alkyl, or alkylcarbonyl.

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Pandya et al., “s-Triazinyl Derivatives As Medicinal Agents”, J. Inst. Chemists (India), vol. XLVIII—Part I, Jan. 1976, pp. 245-247.
Pandya et al., “Studies On Potential Drugs:Potential Anthelmintics Part I”, J. Inst. Chemists (India), vol. XLVII, Nov., 1975, pp. 235-237.
Azev et al.., “Synthesis And Biological Activity Of Cyanomethoxy-s-Triazines”, Translated from Khimiko-Farmatsevticheskii Zhurnal, vol. 25, No. 10, pp. 43-46, Oct., 1991.
Jelene et al., “Synthesen von substituierten 1,3.5-Triazinen and über eine neuartige Synthese substituierter s-Triazolo [4.3-a]”, Monatshefte Für Chemie, 1966, pp. 1714-1722.
Pearlman et al., “Alkoxy-s-triazines. II”, The Journal of the American Chemical Society, vol. LXXI, Jan.-Apr. 1949, pp. 1128-1129.
Chemical Abstracts, No. 172619t, vol. 82, No. 25, Jun., 1975, p. 91.
Chemical Abstracts, Nos. 14188k; 141882d; 141884f; 141885g and 141887j., vol. 74, No. 25, Jun. 1971, p. 601.
BE 660,634 A (Badische Anilin & Soda Fabrik A.-G.) Sep. 6, 1965, see pp. 6-7, example 3.
Trinchieri, G., “Function and clinical use of interleukin-12.” Curr. Opin. Hematol., vol. 4, No. 1, Jan. 1997, pp. 59-66.
International Search Report dated Jun. 12, 2003.

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