Triazine carboxylic acids and esters

Details Triazine carboxylic acids and esters Triazine carboxylic acids and esters

1990-02-13

1991-06-04

Ford, John M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544182, A61K 3153, C07D25306

Patent

active

050214152

ABSTRACT:
Heterocyclic acids and esters useful as inhibitors of mammalian blood platelet aggregation characterized by Formula I or II are disclosed. ##STR1## Formula I compounds are those wherein n is 6-9, R is hydrogen, lower alkyl or an alkali metal ion, and HET.sub.1 is the heterocyclic radical 2,3-dihydro-3-oxo-5,6-diphenyl-1,2,4-triazin-2-yl.
Formula II compounds are those wherein R.sub.1 is hydrogen, lower alkyl or an alkali metal ion, and the radical --OCH.sub.2 CO.sub.2 R is attached in the 3 or 4 ring position; and HET.sub.2 is the heterocyclic radical 2,3-dihydro-3-oxo-5,6-diphenylmethyl-1,2,3-triazin-2-yl.

REFERENCES:
patent: 4167566 (1979-09-01), Petit et al.
patent: 4318911 (1982-03-01), Lacefield
patent: 4511566 (1985-04-01), Petit et al.
patent: 4677105 (1987-06-01), Guy et al.
patent: 4851411 (1989-07-01), Petit et al.

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