Triazine based ligands and use thereof

Details Triazine based ligands and use thereof Triazine based ligands and use thereof

1998-05-01

2000-09-12

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544215, 2101982, C07D25102

Patent

active

061179965

ABSTRACT:
The present invention relates to novel affinity ligand-matrix conjugates comprising a ligand with the general formula (a) ##STR1## which ligand is attached to a support matrix in position (A), optionally through a spacer arm interposed between the matrix and ligand. The invention furthermore relates to these novel affinity ligand-matrix conjugates and the preparation and use thereof in the purification of proteinaceous materials such as e.g. immunoglobulins, insulins, Factor VII, or human Growth Hormone or analogues, derivatives and fragments thereof and precursors.

REFERENCES:
Atkinson et al., Affinity Chromatography and related techniques, 1982, Elsevier.
Konieczny, M. et al., Arch Immunol. Ther. Exp., vol. 30, No. 1, pp. 1-9 (1982).
Burton, N.P. et al., J. Mol. Recogn., vol. 5, pp. 55-68 (1992).
Burton, S.J. et al., J. Chrom., vol. 508, pp. 109-125, (1990).
Atkinson, A. et al., "The Potential of Organic Dyes as Affinity Ligands in Protein Studies", In:Affinity Chromatography and Related Techniques, Proc. 4th Int. Symp. Edited by T.C.J. Gribnau et al., Elsevier Sci. Publ., Amsterdam, Anal. Chem. Symp. Series, 1982, vol. 9, pp. 399-410.

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