Triaza macrocycles

Details Triaza macrocycles Triaza macrocycles

1995-06-06

1996-10-15

Datlow, Philip I.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

540474, C07D25502

Patent

active

055655629

ABSTRACT:
Triaza macrocycles carrying a -CH.sub.2 COOH, -CH.sub.2 CONR.sup.6 R.sup.7, --CH.sub.2 P(R.sup.5)O.sub.2 H, or --CH.sub.2 PO.sub.3 H.sub.2 group on two of the three ring nitrogen atoms and a --CH(L--Z)COOH, --CH(L--Z)CONR.sup.6 R.sup.7, --CH(L--Z)P(R.sup.5)O.sub.2 H, or --CH(L--Z)PO.sub.3 H.sub.2 group on the third ring nitrogen atom, in which L is an organic linking radical and Z is any group capable of reacting with a thiol, amino, carboxy, hydroxyl, aldehyde, aromatic, or heteroaromatic group, and metal complexes thereof, are useful for imaging, diagnosis, and therapy. A typical embodiment is N-[5-carboxy-5-{4,7-bis-(carboxymethyl)-1,4,7-triazacyclonon-1-yl}pentyl] 3-maleimidopropionamide.

REFERENCES:
patent: 4174319 (1979-11-01), Kobuke
patent: 4174428 (1979-11-01), Tabushi et al.
patent: 4432907 (1984-02-01), Wieder et al.
patent: 4472509 (1984-09-01), Gansow et al.
patent: 4659839 (1987-04-01), Nicolotti et al.
patent: 4671958 (1987-06-01), Rodwell et al.
patent: 4678667 (1987-07-01), Meares
patent: 4877600 (1989-10-01), Bonnemain et al.
patent: 4885363 (1989-12-01), Tweedle et al.
patent: 5049667 (1991-09-01), Schaefer et al.
patent: 5053503 (1991-10-01), Dean et al.
patent: 5132409 (1992-07-01), Felder et al.
patent: 5247075 (1993-09-01), Parker et al.
patent: 5374416 (1994-12-01), Rousseaux et al.
Khaw et al, Science. 209, 295 (1980).
Krejcarek et al., Biochem. Biophys. Res. Comm., 77, 581 (1977).
Childs, R. L. and Hnatowich, D. J., J. Nuc. Med. 26, 293 (1985).
Stetter, H., et al., Angew. Chem. Int. Ed. Engl., 15, 686 (1976).
Loncin, J. F., et al., Inorg. Chem., 25, 2646 (1986).
Moi, C. F., et al., J. Am. Chem. Soc., 110, 6266 (1988).
Tweedle, M. F., et al., J. Nuc. Med., 28, 705 (1987).
Goodwin, C. H., et al., J. Nuc. Med., 27, 959 (1986).
Paik, C. H., et al., J. Nuc. Med., 28, 572 (1987).
Paik, C. H., et al., J. Nuc. Med., 29, 889 (1988).
Haseman, C. F., et al., Eur. J. Nuc. Med., 12, 455 (1986).
Parker et al., Pure & Appl. Chem., vol. 61, No. 9, 1637-1641 (1989).
Craig et al., J. Chem. Soc. Chem. Commun. (1989), pp. 794-796.
Cox et al., J. Chem. Soc. Chem. Commun. (1989), pp. 797-798.
Paik et al., J. Nucl. Sci., vol. 30, No. 10, pp. 1693-1701 (Oct. 1989).
Paik et al., Nucl. Med. Biol., vol. 16, No. 5, pp. 475-481 (1989).
Deshpande et al., Nucl. Med. Biol., vol. 16, No. 6, pp. 587-597 (1989).
Deshpande et al., The Journal of Nuclear Medicine. "Copper-67-Labeled Monoclonal Antibody Lym-1, A Potential Radio-pharmaceutical for Cancer Therapy: Labeling and Biodistribution in RAJI Tumored Mice", vol. 29, No. 2, pp. 217-225 (Feb. 1988).
Franz, J., et al., Abstract from Journal of Nuclear Medicine, Abstract No. 553, vol. 26, No. 5 (May 1985).
Meares, Claude F., Protein Tailoring for Food and Medicine Uses edited by R. E. Feeny et al., "Attaching Metal Ions to Antibodies", pp. 339-352 (1986).
Meares et al., Int. J. Cancer Suppl., 2, 99-102 (1988).
Meares et al., Br. J. Cancer, 62, 21-26 (1990).
Gansow et al., ACS Symposium Series, No. 241, p. 215, "Generator Produced Bi-212" (1984).
Moi et al., Anal. Biochem., 148, 249-253 (1985).

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