Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1976-10-18
1977-11-08
Jiles, Henry R.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
548336, 548342, 260239BA, 26029367, 26029368, 26029369, 2602937, 26029372, 26029383, 2602948D, 260296B, 260302H, 2603067R, 260307R, 260307F, 260307G, 260307H, 2603131, 2603265C, 26032655A, 2603269, 260329F, 2603323P, 2603477, 2603478, 424275, 424276, 424285, C07D22122
Patent
active
040575497
ABSTRACT:
The present invention comprehends a method for treating diarrhea comprising administering to an animal in need of anti-diarrheal treatment an effective antidiarrheal amount of a compound of the formula ##STR1## and acid addition salts thereof wherein Y is alkylene containing 1-4 carbon atoms; R.sub.2 and R.sub.3 together with N is a heterocyclic ring system comprising azamonocyclic ring of the forumula ##STR2## wherein Z is phenylhydroxymethylmethylene, phenylhydroxymethylene, phenylcarboxymethylene, phenylcarbalkoxymethylene or azabicycloalkyl or phenyl or hydroxyl substituted azabicycloalkyl containing 6-9 carbon atoms and containing at least 5 atoms in each ring of azabicycloalkyl or 4-azatricyclo[4.3.1.1.sup.3,8 ]undec-4-yl; Ar.sub.1 and Ar.sub.2 are phenyl, halo-substituted phenyl, (lower alkyl) substituted phenyl, pyridyl, thienyl or furyl, and Ar.sub.3 is phenyl, halo-substituted phenyl, (lower alkyl) substituted phenyl, pyridyl, thienyl, furyl, pyrrolyl, imidazoyl, oxazolinyl, oxazolinyl, thiazolinyl, thiazolyl, 1,2,4-oxodiazolyl, and isoxazolinyl. The present invention also comprehends novel compounds included in the above formula.
REFERENCES:
patent: 3272827 (1966-09-01), Pesson
patent: 3917615 (1975-11-01), Adelstein
Patai; S. et al., J. Chem. Soc., 716 (1962).
Martensson; D. et al., Acta Chem. Scand., 19 (3), 711 (1965).
Adelstein Gilbert W.
Dajani Esam Z.
Yen Chung Hwai
G. D. Searle & Co.
Jiles Henry R.
McDonnell John J.
Schwartz Richard A.
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