Triarylmethane derivatives and their use as...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

Reexamination Certificate

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C514S638000, C564S459000, C564S459000, C564S270000, C564S271000, C564S315000, C564S427000, C564S305000

Reexamination Certificate

active

06914078

ABSTRACT:
Disclosed are compounds having one of the following structures:wherein R and R′ are hydrogen or substituted or unsubstituted C1to C6linear or branched alkyl, and at least one X is a halogen atom, pharmaceutical compositions containing the compounds as active ingredients, and methods for using the compounds in the photodynamic treatment of cancers.

REFERENCES:
patent: 2002/0123530 (2002-09-01), Indig
Indig, G., et al., “Effect of Molecular Structure on the Phototoxicity of Triarylmethane Dyes Towards Tumor and Normal Cells,” Abstract, 30thAnnual Meeting of the American Society for Photobiology, Quebec City, Canada, Jul. 13-17, 2002.
Kandela, Irawati K., et al., “Effect of Molecular Structure on the Selective Phototoxicity of Triarylmethane Dyes Towards Tumor Cells,”Journal of Pharmaceutical Sciences, vol. 89, No. 1, Jan. 2000, andPhotochem. Photobiol. Sci., pp. 309-314, 2002.
Fiedorowicz, M. et al., “Efficient Photodynamic Action of Victoria Blue BO Against the Human Leukemic Cell Lines K-562 and TF-1,”Photochemistry and Photobiology, vol. 58, No. 3, pp. 356-361, 1993; published by American Society for Photobiology.
Lewis, M. R. et al., “The Tumor-Inhibitory Activity of Diaryl- and Triarylmethane Dyes,”Cancer Research, vol. 13, pp. 130-136, 1953.
Morgan, A. R. et al., “Synthesis and in vivo Activity of Some Porphyrindione Derivatives with Potential in Photodynamic Therapy,”Journal of Photochemistry and Photobiology, B: Biology, vol. 6, pp. 133-141, 1990; published by Elsevier Sequoia/Printed in The Netherlands.
Morgan, A. R. et al., “Diels-Alder Adducts of Vinyl Porphyrins: Synthesis and in Vivo Photodynamic Effect against a Rat Bladder Tumor,”J. Med. Chem., vol. 33, pp. 1258-1262, 1990; published by American Chemical Society.
Morgan, A. R. et al., “Tin Etiopurpurin Dichloride-Sensitized Lipid Photooxidation of Erythrocyte Membranes,”Photochemistry and Photobiology, vol. 52, No. 5, pp. 987-991, 1990; published by Pergamon Press plc/Printed in Great Britain.
Oseroff, A. R., “Cationic Sensitizers, Combination Therapies, and New Methodologies,”Photodynamic therapy: Basic principles and clinical applications, pp. 79-96, 1992; published by Dekker, New York.
Patel, J. et al., “Design of Novel Analogs of Victoria Blue BO (VBBO) for Photodynamic Therapy,”Abstracts of Papers of the American Chemical Society, vol. 203, Apr. 5-10, 1992, San Francisco, California.
Riley, J. F., M.D., “Retardation of Growth of a Transplantable Carcinoma in Mice Fed Basic Metachromatic Dyes,”Cancer Resaerch, vol. 8, pp. 183-188, 1948.
Wadwa, K. et al, “Cationic Triarylmethane Photosensitizers for Selective Photochemotherapy: Victoria Blue-BO, Victoria Blue-R and Malachite Green,”Advances in Photochemotherapy, vol. 997, pp. 154-161, 1988.

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