Triaryl-oxy-aryloxy-pyrimidine-2,4,6-trione...

Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C544S300000, C544S301000, C544S302000, C544S303000, C544S304000, C544S306000, C544S307000, C514S270000

Reexamination Certificate

active

07119201

ABSTRACT:
The present invention relates to triaryl-oxy-aryloxy-pyrimidine-2,4,6-trione; metalloproteinase inhibitors of the formulawherein X, A, Y, B, G, W, and R1are as defined in the specification, and to pharmaceutical compositions and methods of treating inflammation, cancer and other disorders.

REFERENCES:
patent: 6579982 (2003-06-01), Blagg
patent: 2002/0132822 (2002-09-01), Noe et al.
patent: 2003/0096803 (2003-05-01), Noe et al.
patent: 2003/0225056 (2003-12-01), Freeman-Cook et al.
patent: 2004/0006057 (2004-01-01), Reiter et al.
patent: 2004/0010141 (2004-01-01), Noe et al.
patent: 606046 (1994-07-01), None
patent: 98/58925 (1998-12-01), None
patent: 00/47565 (2000-08-01), None
Mitchell, G. et al., “Cloning, Expression, and Type II Collagenolytic Activity of Matrix Metalloproteinase-13 from Human Osteoarthritic Cartilage,”J. Clin. Invest., 97, pp. 761-768, (1996).
Goodman, et al.,The Pharmacological Basis of Therapeutics, 8thEd., 345-382, (1990).
Lednicer,et al.,The Organic Chemistry of Drug Synthesis, 1, 167-277.
Niederl, J.B. et al., “Disproportionation in Aryloxymalonic Acid Syntheses,”J. Amer. Chem Soc., 62, 1154-1156, (1940).
Campbell, M. et al., “The Preparation and Crystal Structure of 2-Phenoxypropenoic Acid,”Aust. J. Chem., 45, 2061-2066, (1992).
Peace, B.W. et al., “The Soluble Copper (I)-Catalyzed Decomposition of Dimethyl Diazomalonate and Di-t-butyl Diazomalonate in the Presence of Some Cycloalkenes,”Synthesis, 12, 658-662, (1971).
Mitsonubu, O., “The Use of Diethyl Azodicarboxylate and Triphenylphosphine in Synthesis and Transformation of Natural Products,”Synthesis, 1, 1-28, (1981).
Vida, J.A. et al., “Analgesics. 1. Selected 5-Substituted 5-Propionoxybarbituric Acids,”J. Med. Chem., 17, pp. 732-736, (1974).
Tate, J.V., et al., “Preparation of 5-Substituted Benzylbarburituric Acids and Investigation of the Effect of the Benzyl and Substituted Benzyl Groups on the Acidity of Barbituric Acid,”J. Het. Chem., 23(1), 9-11 (1986).
Hartwig, J.F., “Transition Metal Catalyzed Synthesis of Arylamines and Aryl Ethers from Aryl Halides and Triflates: Scope and Mechanism,”Angew. Chem. Int. Ed. Engl., 37,(13/14), 2046-2067, (1998).
Cawston, et al., “A Rapid and Reproducible Assay for Collagenase Using [1-14C] Acetylated Collagen,”Anal. Biochem. 99(2), pp. 340-345, (1979).
Johnson-Wint, B., “A Quantitative Collagen Film Collagenase Assay for Large Numbers of Samples,”Anal. Biochem., 104(1), 175-181, (1980).
Whitney, S.E., et al., “Benzyne-Oxazole Cycloadducts: Isolation and Retro-Diels-Alder Reactions,”J. Org. Chem., 55 (3), 929-935, (1990).
Kashima, C. et al., “Synthesis of 2-Aryl-and 5-Alkyl-2-aryloxazoles from 2-Aryl-5-bromooxazoles,”Synthesis, 11, 873-874, (1989).
Gangloff, A.R. et al, “Synthesis of 3,5-disubstituted-1,2,4-oxadiazoles using tetrabutylammonium fluoride as a mild and efficient catalyst,”Tetrahedron Letters, 42(8), 1441-1443, (2001).
Blackhall, A. et al, “Substitution Reactions of Phenylated Aza-heterocycles. Part 1.,”J. Chem. Soc. Perkin Transactions II, 773-777, (1980).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Triaryl-oxy-aryloxy-pyrimidine-2,4,6-trione... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Triaryl-oxy-aryloxy-pyrimidine-2,4,6-trione..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Triaryl-oxy-aryloxy-pyrimidine-2,4,6-trione... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3713425

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.